Sodium Correction for Hyperglycemia

Calculates the actual sodium level in patients with hyperglycemia.

Corrected Sodium (Katz, 1973) = Measured sodium + 0.016 * (Serum glucose - 100)

Corrected Sodium (Hillier, 1999) = Measured sodium + 0.024 * (Serum glucose - 100)

*Hillier et. al (1999) evaluated 6 healthy subjects, induced hyperglycemia, and measured actual serum sodium levels, finding a sodium correction factor of 2.4mEq/L to be more accurate than the classically taught 1.6mEq/L correction factor from Katz, 1973.

Katz MA. Hyperglycemia-induced hyponatremia--calculation of expected serum sodium depression. N Engl J Med. 1973 Oct 18;289(16):843-4. PubMed PMID: 4763428.

Hillier TA, Abbott RD, Barrett EJ. Hyponatremia: evaluating the correction factor for hyperglycemia. Am J Med. 1999 Apr;106(4):399-403. PubMed PMID: 10225241.

Posted in: Critical Care • Endocrine/Metabolic • Endocrinology