A venous blood gas often correlates well with arterial blood gas findings (except for PaO2) unless values are extremely abnormal, and can often be used successfully as a screening tool.
This tool, developed by Jonathan Chen, MD first determines the primary process by looking at the pH and the PCO2. It then calculates compensations to determine chronicity, compensatory, and co-existing acid-base disturbances.
Facts & Figures
Metabolic Acidosis (Anion Gap)
Diabetic Ketoacidosis (check serum ketones)
Propylene Glycol (in BZD drips) or Paraldehydes
Lactic Acidosis (check serum lactate)
Ethylene Glycol (anti-freeze)
Glycols (ethylene or propylene)
Oxoporin (reflects fatty liver damage from glutathione consumption, e.g. acetaminophen toxicity)
D-Lactate (bacterial form)
Renal Failure (BUN uremia)
Metabolic Acidosis (Non-Anion Gap)
Diarrhea / Laxatives
Fistula, (pancreatic, biliary)
Uretero-intestinal diversion (ileal conduit)
Renal Tubular Acidosis (Type 1 Distal or Type 2 Proximal)
Jonathan Chen, MD, PhD is a research fellow in medical informatics, based at the Veteran Affairs Hospital in Palo Alto and Stanford University. He completed the Stanford Internal Medicine residency program and was in the Medical Scientist Training Program (MSTP) and Biomedical Informatics Training (BIT) program at UC Irvine. Dr. Chen co-founded Reaction Explorer, LLC, which offers a unique system for teaching complex problem-solving in organic chemistry with the aid of expert system technology.
To view Dr. Chen's publications, visit his website