ATRIA Bleeding Risk Score
- The ATRIA risk scoring scheme, in combination with other risk stratification scores and physician gestalt, can be used to help guide the decision for warfarin therapy in patients in need of anticoagulation.
- The ATRIA risk scoring scheme may be used as one potential tool to stratify the risk of major hemorrhage in patients in whom warfarin anticoagulation is being considered.
The ATRIA study sought to develop a risk stratification score to predict warfarin-associated hemorrhage.
- Included patients from the Kaiser Permanente of Northern California hospital system with non-valvular, non-transient atrial fibrillation via their ICD-9 codes and then followed up for a period of six to seven years.
- Patients randomly divided into split-sample “derivation” and “validation” cohorts, in a 2:1 ratio, respectively.
- The study sought to identify risk factors for patients with major hemorrhage, defined as fatal, requiring transfusion of ≥ 2 units pRBCs, or hemorrhage into critical anatomic site (intracranial, retroperitoneal, etc).
- Five variables were derived after statistical analysis and then weighed based on degree of effect.
- Scoring system consisted of five criteria, each of which was worth 1, 2, or 3 points.
- Study used ≤ 3 points to define low probability group (<1%) for major hemorrhage, 4 points for immediate (2.6%) and 5-10 points for high (5.8%).
Points to keep in mind:
- Patients at risk for major hemorrhage, e.g. those with past intracranial bleeds, were likely already pre-excluded by clinicians and thus not included in the study
- The derivation and validation cohorts were taken from the same patient population with excellent follow-up
- Patients’ INRs and potential for compliance were not taken into consideration
- The study did not compare the ATRIA score to the HAS-BLED score, which has been incorporated into European and Canadian atrial fibrillation guidelines
- Subsequent studies comparing the performance of the ATRIA and HAS-BLED bleeding risk-prediction scores showed that HAS-BLED had better prediction accuracy than ATRIA.
Considers major and minor risk of hemorrhage and bleeding in patients prior to beginning warfarin therapy
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- <4 points - low risk
- 4 points - intermediate risk
- >4 points - high risk
Patient specific risks and benefits of anticoagulation must be carefully weighed in all patients who are potential candidates for long-term warfarin therapy.
Addition of the selected points, see below:
Facts & Figures
|Risk Factor||Point Value|
|Severe Renal Disease/Dialysis||+3|
|Age ≥ 75||+2|
Original/Primary ReferenceFang MC, Go AS, Chang Y, et al. A New Risk Scheme to Predict Warfarin-Associated Hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol. 2011;58(4):395-401. doi:10.1016/j.jacc.2011.03.031.
ValidationLip GY, Frison L, Halperin JL, Lane DA. Comparative validation of a novel risk score for predicting bleeding risk in anticoagulated patients with atrial fibrillation: the HAS-BLED (Hypertension, Abnormal Renal/Liver Function, Stroke, Bleeding History or Predisposition, Labile INR, Elderly, Drugs/Alcohol Concomitantly) score. J Am Coll Cardiol. 2011 Jan 11;57(2):173-80. doi: 10.1016/j.jacc.2010.09.024. Epub 2010 Nov 24.
About the Creator
Daniel Singer, MD, is a professor of medicine at Harvard Medical School and professor in the Department of Epidemiology at Harvard School of Public Health. He is also chief of the Clinical Epidemiology Unit in the General Medicine Division at Massachusetts General Hospital (MGH). Dr. Singer is internationally recognized for his research on prevention of stroke in atrial fibrillation (AF).
To view Dr. Daniel Singer's publications, visit PubMed