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    Cryoprecipitate Dosing for Fibrinogen Replacement

    Estimates volume of cryoprecipitate recommended for fibrinogen replacement.


    This dosing tool is intended to assist with calculation, not to provide comprehensive or definitive drug information. Always double-check dosing of any drug and consult a pharmacist when necessary.

    When to Use
    Why Use
    • Patients with isolated or exaggerated acquired decreases in fibrinogen (hypofibrinogenemia or hyperfibrinolysis) requiring transfusion with cryoprecipitate (also referred to as cryo and cryoprecipitated antihemophilic factor).
    • Do not use to dose other factors found in cryo (e.g. Factor XIII, Factor VIII, von Willebrand Factor) or to dose fibrinogen concentrate. 
    • For the bleeding patient, target fibrinogen levels of 150-200 mg/dL are often appropriate to ensure adequate hemostasis, and may be generally utilized as end points for desired fibrinogen increments (although individual goals may vary on a case-by-case basis).
    • As a small volume product (generally 5-20 mL of plasma per individual unit) cryo may be preferred over fresh frozen plasma (FFP) for fibrinogen replacement.
    • Primarily for use in adults.
    • If not all clinical or laboratory values are readily available for use in the equation, a commonly used shortcut is administration of one unit of cryo for every 7-10 kg of body weight of the recipient, which should result in a fibrinogen increase of 50-75 mg/dL in general.

    Cryoprecipitate is an important, but seldom used, blood component and providers seeking to administer this product may not be aware of appropriate dosing strategies. This calculation should promote accurate and evidence-based dosing of this blood product.



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