Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

    Disease

    Select...

    Specialty

    Select...

    Chief Complaint

    Select...

    Organ System

    Select...

    Patent Pending

    Log In

    Show
    Forgot your password?
    Log In
    Or create a new account (it's free)

    Forgot Password?

    Enter your email address and we'll send you a link to reset your password.

    Get New Password

    Sign In Required

    To save favorites, you must log in.

    Creating an account is free, easy, and takes about 60 seconds.

    Already have an MDCalc account?

    Login to link your favorites and recently used calcs

    Show
    Forgot your password?
    Log In
    Or continue to Nuance

    Attention COACH STUDY participants:

    The principal investigators of the study request that you use the official version of the modified score here.

    Therapeutic Plasmapheresis Calculator

    Estimates amount of a substance (e.g. antibody) remaining in the intravascular space after a given number of plasma volume exchanges.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients who require therapeutic plasma exchange typically have a pathologic substance in circulation (e.g. an autoantibody) requiring removal. The amount of this substance remaining varies with the number of plasma volumes exchanged, with a plateau typically reached over time as the efficiencies of the procedure are reduced as higher amounts of replacement fluids are removed than the substance initially targeted.

    • This is a theoretical calculation applicable primarily to plasma exchange procedures; removal efficiencies will vary somewhat in practice based on what is being removed and its total body distribution.
    • The equation assumes a strictly intravascular substance; this is not necessarily true in routine clinical practice and the less intravascular a substance, the poorer the efficiency of removal.
    • Can be useful to determine the number of plasma volumes to be exchanged to achieve a reduction in a targeted substance, particularly at the onset of a therapeutic plasma exchange procedure.
    • Provides a sense of the futility of doing many plasma exchanges, as it shows the degree of diminishing returns once a plateau for efficient removal is reached.
    mL
    mL

    Result:

    Please fill out required fields.

    Next Steps
    Evidence
    Creator Insights
    OTHER

    About the Creator

    Other creator.

    Content Contributors
    About the Creator
    OTHER
    Content Contributors