Cytokine Release Syndrome (CRS) Grading
Assesses severity of CRS in patients on immunotherapy.
INSTRUCTIONS
Use in patients receiving immunotherapy for cancer.
When to Use
Pearls/Pitfalls
Why Use
Symptoms not life-threatening; only symptomatic treatment required (fever, nausea, fatigue, headache, myalgias, malaise)
Moderate intervention required for response: oxygen requirement <40%, hypotension responsive to fluids, low dose of one pressor, or grade 2 organ toxicity
Aggressive intervention required for response: oxygen requirement ≥40%, hypotension requiring high dose/multiple pressors, grade 3 organ toxicity, or grade 4 transaminitis
Life-threatening symptoms: ventilator required, or grade 4 organ toxicity (excluding transaminitis)
Death
Result:
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