CLIF-C ACLF (Acute-on-Chronic Liver Failure)
Predicts mortality in acute-on-chronic liver failure.
INSTRUCTIONS
Use in adult patients with decompensated chronic (cirrhotic) liver disease; it does not predict outcome in acute liver failure.
When to Use
Pearls/Pitfalls
Why Use
years
× 10³ cells/µL
Liver
<6 mg/dL (<102.6 µmol/L)
+16 to <12 mg/dL (102.6 to <205.2 µmol/L)
+2≥12 mg/dL (≥205.2 µmol/L)
+3Kidney
<2 mg/dL (<176.8 µmol/L)
+12 to <3.5 mg/dL (176.8 to <309.4 µmol/L)
+2≥3.5 mg/dL (≥309.4 µmol/L) or renal replacement therapy
+3Brain
0
+11-2
+23-4
+3Coagulation
<2.0
+12.0 to <2.5
+2≥2.5
+3Circulatory
≥70
+1<70
+2Any MAP with vasopressors
+3Respiratory
PaO₂/FiO₂ ratio
SpO₂/FiO₂ ratio
>300
+1>200 to 300
+2≤200 (or if patient intubated for respiratory failure)
+3Result:
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Evidence
Creator Insights
- Callum Wood, MB, BChir, MRCP (UK)
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