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    US (MEDPED) Diagnostic Criteria for Familial Hypercholesterolemia (FH)

    Diagnoses familial hypercholesterolemia using age, family history, and total cholesterol.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with suspected familial hypercholesterolemia (FH), including those with elevated cholesterol and/or personal or family history of premature cardiac events.

    Uses three easily obtainable parameters to diagnose familial hypercholesterolemia.

    • FH is underdiagnosed and carries significant mortality risk from cardiac events.
    • Alternative diagnostic criteria include the Dutch Criteria and the Simon Broome Diagnostic Criteria. Of the three, MEDPED is the only one that does not require genetic testing for diagnosis.
    • The risk factors in each criteria set are similar, and clinical judgment as well as local practice factors (similarity of target population to study population) should be considered.
    <20
    20-29
    30-39
    >40
    1st Degree
    2nd Degree
    3rd Degree
    mg/dL

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    Next Steps
    Evidence
    Creator Insights
    Dr. Roger R. Williams

    About the Creator

    Roger R. Williams, MD, (d. 1998) was a professor of internal medicine at the University of Utah School of Medicine. He was the founder and director of the University of Utah Cardiovascular Genetics Research Clinic. Williams was an active researcher helping develop effective tools for evaluating and helping families with strong familial predisposition to early coronary disease, stroke, hypertension, diabetes, breast cancer and morbid obesity

    To view Dr. Roger R. Williams's publications, visit PubMed

    About the Creator
    Dr. Roger R. Williams