Ginsberg JM, Chang BS, Matarese RA, Garella S. Use of single voided urine samples to estimate quantitative proteinuria. N Engl J Med. 1983 Dec 22;309(25):1543-6.

Siwach SB, Kalra OP, Sharma R, Singh V, Chopra JS. Estimation of 24 hour protein excretion from single random urine specimen. Indian J Med Res. 1990 Apr;92:105-8.

Schwab SJ, Christensen RL, Dougherty K, Klahr S. Quantitation of proteinuria by the use of protein-to-creatinine ratios in single urine samples. Arch Intern Med. 1987 May;147(5):943-4.

Houser M. Assessment of proteinuria using random urine samples. J Pediatr. 1984 Jun;104(6):845-8.

Neithardt AB, Dooley SL, Borensztajn J. Prediction of 24-hour protein excretion in pregnancy with a single voided urine protein-to-creatinine ratio. Am J Obstet Gynecol. 2002;186(5):883-6.

Price CP, Newall RG, Boyd JC. Use of Protein:Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review. Clinical Chemistry 2005; v. 51, p.1577-1586. Published July 14, 2005.

Dr. Jay M. Ginsberg

//outputs
var calc_output = [];

//user inputs
if (UOMSYSTEM == false) {
var pro = parseFloat(pro)/10;
var cre = parseFloat(cre) / (88.42*1000);
}

if (UOMSYSTEM == true) {
var pro = parseFloat(pro);
var cre = parseFloat(cre) / 1000;
}


//calculation
var u = pro / cre;

var msg;
if (u < 200){
	msg = "Within normal limits.";
}
if (u >= 200 && u <= 3500){
	msg = "Elevated urinary protein. Investigate further.";
}
if (u > 3500){
	msg = "Nephrotic range.";
}

var upee = u/1000;

//result user sees
calc_output.push({
name: 'mini',
value: upee.toFixed(1),
value_text: 'g/day',
message: '24 hour UPEE'
});

calc_output.push({
name: 'Calc',
value: u.toFixed(0),
value_text: 'mg/g',
message: 'Urine protein/creatinine ratio'
});

calc_output.push({
name: 'UPEE',
value: upee.toFixed(1),
value_text: 'g/day',
message: 'Estimated 24 hour urinary protein excretion ' + msg
});

Urinary Protein Excretion Estimation

Quantifies 24-hour proteinuria with protein/creatinine ratio from a single urine sample.

Chetana Pendkar, MBBS, is a pulmonary critical care fellow at SUNY Downstate in Brooklyn, New York. Born and raised in Mumbai, she received her MBBS from Lokmanya Tilak Municipal Medical College, Mumbai. Dr. Pendkar completed her internal medicine residency at Maimonides Medical Center in Brooklyn. Her clinical interests include pulmonary physiology, ventilation, and extracorporeal membrane oxygenation.

Chetana Pendkar, MBBS

The Urinary Protein Excretion Estimation quantifies 24-hour proteinuria using protein/creatinine ratio from a single urine sample.

Urine protein, random

Urine creatinine, random

Urine Output

RUIS (Urinary Incontinence) Score

Revised Schwartz Equation (2009)

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Calc Function