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    Chief Complaint


    Organ System


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    Plasma Dosage

    Doses plasma for transfusion in patients with active bleeding.


    This dosing tool is intended to assist with calculation, not to provide comprehensive or definitive transfusion information. Always double-check dosing of any drug and consult a pharmacist or clinical pathologist as necessary.


    Absolute contraindications to transfusion of fresh frozen plasma (FFP): documented intolerance to plasma or components, congenital IgA deficiency with anti-IgA antibodies, etc. Relative contraindications: heart failure, pulmonary edema, etc. Plasma should be ABO-compatible with recipient.

    When to Use
    • Use to correct deficiencies of clotting factors, for which a specific concentrate is not available, in patients with active bleeding.
    • Inappropriate indications include transfusion in patients without active bleeding or invasive procedures, correction of minimal elevations in INR (i.e., INR <1.7), expansion of circulatory volume, hypoproteinemia, correction of immune deficiencies, transfusion for nutritional purposes, correction of congenital or acquired deficiencies of clotting factors in the absence of hemorrhage, or correction of disorders of hemostasis in patients with chronic liver disease who are not bleeding.
    • Transfusion of less than the therapeutic dose of plasma should be discouraged.  
    • Plasma should be infused as soon as possible after it is thawed and never be refrozen.  
    • Precise prediction of the amount of plasma needed to be transfused to correct a particular coagulopathy is not currently possible. Thus, post-transfusion repetition of the coagulation test that prompted the transfusion is warranted.


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