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    Attention COACH STUDY participants:

    The principal investigators of the study request that you use the official version of the modified score here.

    Corrected Count Increment (CCI) for Platelet Transfusion

    Assesses adequacy of response to platelet transfusion.
    When to Use
    Pearls/Pitfalls
    Why Use

    Use in patients undergoing platelet transfusion.

    • Corrected count increment (CCI) is a measure of the expected increase in platelets following a platelet transfusion. The “count increment” refers to the increase in platelets following a transfusion. The “correction” is based on the patient’s size and the number of platelets transfused. 
    • Refractory = failure to achieve acceptable increase in platelet count following platelet transfusion on at least two occasions and no alternate cause for refractoriness such as fever, sepsis, DIC, bleeding, splenomegaly, or drug interaction (e.g. amphotericin B).
    • Response to platelet transfusion is typically measured within one hour. However, a sample collected 10 minutes after transfusion yields similar information and may be easier to obtain routinely. A post-transfusion platelet count can alternatively be taken at 20 hours.
    • CCI is a more accurate measure of refractoriness, as it adjusts for the number of platelets transfused and the patient's blood volume.
    • Can guide the decision to pursue platelets with improved compatibility (i.e., HLA-matched platelets).
    × 10³/µL
    × 10³/µL
    1-hour
    20-hour
    in
    lbs
    × 10¹¹ plts

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