Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31-41. PubMed PMID: 1244564.

Winter MA, Guhr KN, Berg GM. Impact of various body weights and serum creatinine concentrations on the bias and accuracy of the Cockcroft-Gault equation. Pharmacotherapy. 2012 Jul;32(7):604-12. doi:10.1002/j.1875-9114.2012.01098.x. Epub 2012 May 10. PubMed PMID: 22576791.

Brown DL, Masselink AJ, Lalla CD. Functional range of creatinine clearance for renal drug dosing: a practical solution to the controversy of which weight to use in the Cockcroft-Gault equation. Ann Pharmacother. 2013 Jul-Aug;47(7-8):1039-44. doi: 10.1345/aph.1S176. Epub 2013 Jun 11. Review. PubMed PMID: 23757387.

Dr. Donald Cockcroft

Dr. Henry Gault

//declare calc_output
var calc_output = [];

//user inputs:
var cr = UOMSYSTEM ? parseFloat(creatinine) : (parseFloat(creatinine) / 88.4)
var weight = parseFloat(weight); // no need to adjust. weight always comes in in SI system
var sex = parseFloat(sex)
var age = parseFloat(age)

//derived variables from user inputs
var sexPts;
var wtCorrection;
if (sex === 0) {
 sexPts = 1;
 wtCorrection = 50;
} else if (sex === 1) {
 sexPts = 0.85;
 wtCorrection = 45.5;
}

//calculate result1
var result1 = (((140 - age) * weight * sexPts) / (72 * cr));

//determine msg1
var msg1 = 'Creatinine clearance, original Cockcroft-Gault'

 calc_output.push({
 name: 'mini',
 value: result1.toFixed(0),
 value_text: 'mL/min',
 message: 'Creatinine clearance'
 });

//if the user did not enter height or the height is 0
if (!parseFloat(height)) {
 calc_output.push({
 name: '43_Creatinine Clearance_result (original)',
 value: result1.toFixed(0),
 value_text: 'mL/min',
 message: msg1
 });
}

//if the user entered height that's not 0
if (parseFloat(height)) {

 var ht = parseFloat(height); // height in cm, BUT OF COURSE WE NEED FREAKING INCHES
 var ht_inches = ht / 2.54; // height in inches
 var ibw = (ht_inches <= 60) ? wtCorrection : (wtCorrection + 2.3 * (ht_inches - 60))
 var ibw_crcl = ((140 - age) * ibw * sexPts) / (72 * cr); // if pt was ideal body weight, this would be their CrCl. used below.
 var bmi = weight / Math.pow(ht / 100, 2); // weight already in kg, ht in cm so divide by 100 to get ht in meters for correct bmi formula

 switch (true) {

 case (bmi > 0 && bmi < 18.5):
 calc_output.push({ // add the modified CrCl for weight here
 name: '43_Creatinine Clearance_result (modified)',
 value: result1.toFixed(0),
 value_text: 'mL/min',
 message: 'Creatinine clearance for underweight patient (BMI ' + bmi.toFixed(1) + ' kg/m²), calculated using actual body weight (no adjustment).'
 })
 break

 case (bmi >= 18.5 && bmi < 25): // intermed BMI so check wt vs IBW

 calc_output.push({
 name: '43_Creatinine Clearance_result (original)',
 value: result1.toFixed(0),
 value_text: 'mL/min',
 message: msg1
 });

 var value_corrected = (140 - age) * ibw * sexPts / (72 * cr);

 var msgAppend = '';
 if (weight.toFixed(0) == ibw.toFixed(0)) {
 msgAppend = 'normal weight patient. Note: This patient\'s IBW is equal to their actual weight, so this is likely near their true CrCl and no adjustment is made.';
 } else {
 msgAppend = 'normal weight patient, using ideal body weight of ' + ibw.toFixed(0) + ' kg (' + (ibw.toFixed(0) * 2.2).toFixed(0) + ' lbs).';
 }
 
 calc_output.push({ // add the modified CrCl for weight here
 name: '43_Creatinine Clearance_result (modified)',
 value: value_corrected.toFixed(0),
 value_text: 'mL/min',
 message: 'Creatinine clearance for ' + msgAppend
 });

 if (weight !== ibw) {
 var range;
 if (weight > ibw) {
 range = ibw_crcl.toFixed(1) + '-' + result1.toFixed(1);
 } else {
 range = result1.toFixed(1) + '-' + ibw_crcl.toFixed(1);
 }
 calc_output.push({
 name: '43_Creatinine Clearance_result (range)',
 value: range,
 value_text: 'mL/min',
 message: "Note: This range uses IBW and actual body weight. Controversy exists over which form of weight to use."
 });
 }
 break

 case (bmi >= 25):

 calc_output.push({
 name: '43_Creatinine Clearance_result (original)',
 value: result1.toFixed(0),
 value_text: 'mL/min',
 message: msg1
 });

 var abw = ibw + 0.4 * (weight - ibw); // adjusted body weight for obesity
 var abw_lbs = abw * 2.2
 var value_corrected = (140 - age) * abw * sexPts / (72 * cr);

 calc_output.push({ // add the modified CrCl for weight here
 name: '43_Creatinine Clearance_result (modified)',
 value: value_corrected.toFixed(0),
 value_text: 'mL/min',
 message: 'Creatinine clearance modified for overweight patient, using adjusted body weight of ' + abw.toFixed(0) + ' kg (' + abw_lbs.toFixed(0) + ' lbs).'
 });

 if (ibw_crcl !== value_corrected) {
 var range;
 if (ibw_crcl < value_corrected) {
 range = ibw_crcl.toFixed(1) + '-' + value_corrected.toFixed(1);
 } else {
 range = value_corrected.toFixed(1) + '-' + ibw_crcl.toFixed(1);
 }
 }

 calc_output.push({
 name: '43_Creatinine Clearance_result (range)',
 value: range,
 value_text: 'mL/min',
 message: "Note: This range uses IBW and adjusted body weight. Controversy exists over which form of weight to use."
 });
 break
 default:
 break
 }
}

Creatinine Clearance (Cockcroft-Gault Equation)

weight

creatinine

height

Calculates CrCl according to the Cockcroft-Gault equation.

Estimates creatinine clearance (kidney function).

Creatinine Clearance

Evan Zeitler, MD, is a nephrology fellow at UNC Chapel Hill in North Carolina. He has spent his medical career at UNC, completing medical school, residency, and a nephrology fellowship there. He is passionate about medical education, chronic kidney disease, and acid-base disorders. Dr. Zeitler's primary research is focused on obesity and its downstream effects on kidney metabolism and health.

Evan Zeitler, MD

The Creatinine Clearance (Cockcroft-Gault Equation) predicts Creatinine Clearance from serum Creatinine.

Weight

Creatinine

Height

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Revised Schwartz Equation (2009)

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Calc Function