Rumack BH, Peterson RC, Koch GG, Amara IA. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med. 1981;141:380-5.

Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. BMJ. 1979;2:1097-1100.

Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N-acetylcysteine in the treatment of acetaminophen overdose: Analysis of the National Multicenter Study. N Engl J Med. 1988;319:1557-62.

Dr. Barry H. Rumack

Acetaminophen Overdose and NAC Dosing

nac_route

weight

Calculates PO/IV NAC dosing for acetaminophen overdose (and nomogram to determine toxic 4 hour level).

NAC Dosing (Tylenol OD)

Scott Lucyk, MD, is an emergency physician and medical toxicologist with the Poison and Drug Information Service (PADIS) in Calgary, Alberta, Canada. Dr. Lucyk obtained his Fellowship of the Royal College of Physicians of Canada (FRCPC) in emergency medicine from the University of Alberta, followed by a fellowship in medical toxicology at the New York Poison Control Center in New York City. Currently, he is the associate medical director at PADIS and the program director of the clinical pharmacology and toxicology subspecialty in Calgary. Dr. Lucyk focuses his non-clinical time on medical education and resident teaching.

Scott Lucyk, MD

The Acetaminophen Overdose and NAC dosing Calculates PO or IV dosing of N-acetylcysteine (NAC) for acetaminophen overdose.

Weight

King's College Criteria

Neonatal Hyperbilirubinemia Risk

R Factor

EB Medicine is the premier provider of evidence-based clinical content and CME resources for emergency medicine practitioners.

Listen to the VACO co-creators break down how to use VACO\, what it does\, and what it doesn’t.

Calc Function