Calc Function

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    Creatinine Clearance (Cockcroft-Gault Equation)

    Calculates CrCl according to the Cockcroft-Gault equation.
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    When to Use
    Pearls/Pitfalls
    Why Use
    • Assessing a patient's renal function.
    • Prescribing a drug that is renally metabolized.

    From Dan Brown, PharmD, at Palm Beach Atlantic University, the primary author of the functional range of creatinine clearance paper:

    “The Cockcroft-Gault equation remains the gold standard after almost 40 years, despite inaccuracies that arise from variations in body composition among patients. Those who understand potential sources of error can adjust accordingly.”

    • While the Cockcroft-Gault equation is the most well-known and frequently-calculated estimates of GFR (via Creatinine Clearance), other calculators have recently gained attention as better estimates, like the MDRD. (The latter have not been validated in acute renal failure, only patients with chronic kidney disease.)
    • Creatinine clearance is still used as the standard for drug dosing, instead of GFR.
    Female
    Male
    years
    lbs
    mg/dL
    The Cockcroft-Gault Equation may be inaccurate depending on a patient's body weight and BMI; by providing additional height, we can calculate BMI and provide a modified estimate and range.
    in

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    Next Steps
    Evidence
    Creator Insights

    Advice

    After calculating a creatinine clearance, providers should consider calculating an actual GFR as well, to determine the staging/severity of a patient's chronic kidney disease.

    CKD Stage

    GFR, mL/min/1.73 m2

    I

    ≥90

    II

    60–89

    IIIa

    45–59

    IIIb

    30–44

    IV

    15–29

    V

    <15

    About the Creator
    Dr. Donald Cockcroft
    Are you Dr. Donald Cockcroft?
    Dr. Henry Gault
    Are you Dr. Henry Gault?