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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
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    Patent Pending

    Creatinine Clearance (Cockcroft-Gault Equation)

    Calculates CrCl according to the Cockcroft-Gault equation.
    When to Use
    Pearls/Pitfalls
    Why Use
    • Assessing a patient's renal function.
    • Prescribing a drug that is renally metabolized.

    From Dan Brown, PharmD, at Palm Beach Atlantic University, the primary author of the functional range of creatinine clearance paper:

    “The Cockcroft-Gault equation remains the gold standard after almost 40 years, despite inaccuracies that arise from variations in body composition among patients. Those who understand potential sources of error can adjust accordingly.”

    • While the Cockcroft-Gault equation is the most well-known and frequently-calculated estimates of GFR (via Creatinine Clearance), other calculators have recently gained attention as better estimates, like the MDRD. (The latter have not been validated in acute renal failure, only patients with chronic kidney disease.)
    • Creatinine clearance is still used as the standard for drug dosing, instead of GFR.
    Female
    Male
    years
    lbs
    mg/dL
    The Cockcroft-Gault Equation may be inaccurate depending on a patient's body weight and BMI; by providing additional height, we can calculate BMI and provide a modified estimate and range.
    in

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    Next Steps
    Evidence
    Creator Insights
    Dr. Donald Cockcroft

    About the Creator

    Donald W. Cockcroft, MD, is a professor of medicine at the University of Saskatchewan. He is co-chair of Airways Research Group and the chair of the Quality Assurance Committee. Dr. Cockcroft specializes in asthma practice and research.

    To view Dr. Donald Cockcroft's publications, visit PubMed

    Are you Dr. Donald Cockcroft? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Dr. Henry Gault

    About the Creator

    Henry Gault, MD, MSc, (d. 2003) was named professor emeritus in 1993 after nearly 20 years as a physician and professor at Memorial University of Newfoundland. He was also director for the Division of Nephrology at the General Hospital and of the Renal Laboratory. Dr. Gault was a pioneer in the field of nephrology and his work on urine enzymology was a major influence on the discovery of the diagnosis of the rejection of kidney transplants.

    To view Dr. Henry Gault's publications, visit PubMed

    Are you Dr. Henry Gault? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Donald Cockcroft
    Are you Dr. Donald Cockcroft?
    Dr. Henry Gault
    Are you Dr. Henry Gault?