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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





    Chief Complaint


    Organ System


    Patent Pending

    Dutch Criteria for Familial Hypercholesterolemia (FH)

    Diagnoses familial hypercholesterolemia (FH) based on clinical, genetic and family history.
    When to Use
    Why Use

    Patients with suspected familial hypercholesterolemia (FH), including those with elevated cholesterol and/or family history of premature cardiac events.

    • Assigns points to risk factors and stratifies likelihood of diagnosis into one of four categories: definite, probable, possible, and unlikely.
    • Requires DNA testing for completeness.
    • FH is underdiagnosed and carries significant mortality risk from cardiac events.
    • The European Atherosclerosis Society recommends that the Dutch Criteria be used to diagnose FH.
    • Alternative diagnostic criteria include US MEDPED and the Simon Broome Diagnostic Criteria. The risk factors in each criteria set are similar, and clinical judgment as well as local practice factors (similarity of target population to study population) should be considered.
    Entry Criterion

    If yes, 9+ additional criteria required for Definite FH


    Diagnostic Result:

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    Next Steps
    Creator Insights


    Consider lifestyle changes, drug therapy, family testing, and other measures to manage FH if diagnosed.

    About the Creator
    Dr. Melissa Austin
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