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      Calc Function

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    Patent Pending

    Dutch Criteria for Familial Hypercholesterolemia (FH)

    Diagnoses familial hypercholesterolemia (FH) based on clinical, genetic and family history.
    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with suspected familial hypercholesterolemia (FH), including those with elevated cholesterol and/or family history of premature cardiac events.

    • Assigns points to risk factors and stratifies likelihood of diagnosis into one of four categories: definite, probable, possible, and unlikely.
    • Requires DNA testing for completeness.
    • FH is underdiagnosed and carries significant mortality risk from cardiac events.
    • The European Atherosclerosis Society recommends that the Dutch Criteria be used to diagnose FH.
    • Alternative diagnostic criteria include US MEDPED and the Simon Broome Diagnostic Criteria. The risk factors in each criteria set are similar, and clinical judgment as well as local practice factors (similarity of target population to study population) should be considered.
    Entry Criterion

    If yes, 9+ additional criteria required for Definite FH

    No
    Yes

    Diagnostic Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Melissa Austin

    About the Creator

    Melissa Austin, PhD, MS, is a professor emeritus of epidemiology at the University of Washington. Her research spans many areas including genetic epidemiology of chronic diseases, lipoprotein metabolism and pancreatic cancer.

    To view Dr. Melissa Austin's publications, visit PubMed

    Are you Dr. Melissa Austin? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    About the Creator
    Dr. Melissa Austin
    Are you Dr. Melissa Austin?