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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Morphine Milligram Equivalents (MME) Calculator

    Calculates total daily morphine milligram equivalents.

    IMPORTANT

    There is no completely safe opioid dose, and this calculator does not substitute for clinical judgment. Use caution when prescribing opioids at any dosage, and prescribe the lowest effective dose.

    INSTRUCTIONS

    For combination drugs (e.g. Percocet = acetaminophen + oxyCODONE), enter only the dose of the opioid component (e.g. if 5 mg/325 mg, enter "5"). Do not use in pediatric patients, due to unpredictable rates of absorption and risk of overdose.

    When to Use
    Pearls/Pitfalls
    Why Use

    • Use in opioid-naïve and opioid tolerant adult patients.

    • Do not use in pediatric patients, due to unpredictable rates of absorption and risk of overdose.

    • Do not use in patients with malignant pain or those requiring end-of-life care.

    • Uses morphine as the reference point for conversion of other oral opioids to MME.

    • Should be used only for oral opioid conversion to MME, not for conversion of one opioid to another.

    • Equianalgesic dose ratios are approximations and do not account for genetic factors, incomplete cross-tolerance, and pharmacokinetics.

    • Does not give information on efficacy, but is used to assess comparative potency of other analgesics.

    • Pharmacokinetics and conversion for methadone and tapentadol are particularly complex, and clinicians should err on the side of being especially conservative with those conversions in particular.

    • MME is a numerical standard against which most opioids can be compared, yielding a comparison of each medication’s potency.

    • Helps determine whether a cumulative daily dose of opioids is associated with increased risk of overdose.

    • Helps identify patients who may benefit from closer monitoring, reduction or tapering of opioids, naloxone prescription, and other measures to reduce risk of potential opioid abuse and/or overdose.

    Choose one
    mg/dose
    doses/day
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    Yes

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Centers for Disease Control and Prevention

    About the Creator

    The CDC is the leading national public health agency in the US. It focuses on infectious disease, food borne pathogens, environmental health, occupational safety and health, health promotion, injury prevention, and educational activities designed to improve public health. More information can be found on the CDC website.

    To view Centers for Disease Control and Prevention's publications, visit PubMed

    Are you Centers for Disease Control and Prevention? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    • Sergey Motov, MD
    About the Creator
    Centers for Disease Control and Prevention
    Are you Centers for Disease Control and Prevention?
    Content Contributors
    • Sergey Motov, MD