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    Revised McDonald Criteria for Multiple Sclerosis Diagnosis

    Determines presence of MS using MRI findings.
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    The 2010 McDonald Criteria for Diagnosis of MS

    Clinical Presentation Additional Data Needed for MS Diagnosis
    ∙Two or more attacks
    ∙Objective clinical evidence of 2 or more lesions with reasonable historical evidence of a prior attack
    None; clinical evidence will suffice
    Additional evidence (eg, brain MRI) desirable, but must be consistent with MS
    ∙Two or more attacks
    ∙Objective clinical evidence of 1 lesion
    Dissemination in space demonstrated by MRI
    OR
    Await further clinical attack implicating a different site
    ∙One attack
    ∙Objective clinical evidence of 2 or more lesions
    Dissemination in time demonstrated by MRI
    OR
    second clinical attack
    ∙One attack
    ∙Objective clinical evidence of 1 lesion (clinically isolated syndrome)
    Dissemination in space demonstrated by MRI
    OR
    Await a second clinical attack implicating a different CNS site
    AND
    Dissemination in time, demonstrated by MRI or second clinical attack
    ∙Insidious neurologic progression suggestive of MS One year of disease progression and dissemination in space
    AND
    One or more T2 lesions in brain, in regions characteristic of MS
    AND
    Two or more T2 focal lesions in spinal cord Positive CSF
    Notes: An attack is defined as a neurologic disturbance of the kind seen in MS.
    It can be documented by subjective report or by objective observation, but it must last for at least 24 hours.
    Pseudoattacks and single paroxysmal episodes must be excluded.
    To be considered separate attacks, at least 30 days must elapse between onset of one event and onset of another event.