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    tPA (Tissue Plasminogen Activator) Dosing for Stroke Calculator

    Doses tPA for stroke.


    This calculator is for double-checking tPA dosing, and should NOT be used as the primary means for ordering tPA.


    Use in ischemic stroke patients only. Do NOT use in acute coronary syndrome or PE.

    When to Use
    Why Use

    This calculator is intended solely for calculating the alteplase (tPA) dose for ischemic stroke. It does not apply to dosing for acute coronary syndromes or pulmonary embolism.

    • Remember that up to 20 mL (20 mg) tPA will remain in the pump tubing regardless of the method of preparation (withdrawing waste from vial before administration or leaving waste volume in the vial).
    • Standard practice is to infuse up to 50 mL of 0.9% sodium chloride at the same rate after the tPA vial is empty.

    Because of the time-sensitive, high-stress, infrequent nature of ischemic stroke cases receiving tPA, there is risk for medication error. Using a calculator to double check dosing prior to administration can reduce the risk of error.



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    Next Steps
    Creator Insights


    Administer tPA when indicated.


    0.9 mg/kg IV, not to exceed 90 mg total dose.

    Administer 10% of the total dose as an initial IV bolus over 1 minute and the remainder infused over 60 minutes.

    Bryan D. Hayes, PharmD

    About the Creator

    Bryan D. Hayes, PharmD, FAACT, FASHP, is an assistant professor of emergency medicine and clinical pharmacist at Harvard Medical School/Massachusetts General Hospital. He is also an associate editor and the creator of the CAPSULES series of Academic Life in Emergency Medicine (ALiEM). His research interests include toxicology, medication safety and emergency preparedness.

    To view Bryan D. Hayes, PharmD's publications, visit PubMed

    Content Contributors
    • Bryan D. Hayes, PharmD
    About the Creator
    Bryan D. Hayes, PharmD
    Content Contributors
    • Bryan D. Hayes, PharmD