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    Patent Pending

    Urinary Protein Excretion Estimation

    Quantifies 24-hour proteinuria with protein/creatinine ratio from a single urine sample.

    INSTRUCTIONS

    Avoid using overnight or first morning void as urine sample.

    When to Use
    Pearls/Pitfalls
    Why Use
    • Patients in whom renal disease is suspected (to rule out).
    • Patients with known renal disease (to assess progression).
    • Patients with low-grade proteinuria and otherwise intact renal function (to monitor).
    • The Urinary Protein Excretion Estimation (sometimes referred to as “spot urine protein/creatinine ratio” or “protein/creatinine ratio”) calculates the protein/creatinine ratio from a random urine sample to estimate 24-hour protein excretion.
    • Based on the physiologic principle that urinary creatinine excretion is constant if glomerular filtration rate (GFR) is constant and therefore protein/creatinine ratio from a single urine sample should reflect protein excretion, cancelling out the time factor.
    • Confirmed for correlation with 24-hour protein excretion in multiple studies (see Evidence Appraisal/EBM).
    • Correlation is lowest for urine samples voided overnight and upon arising.
    • Can be used only in presence of stable renal function (GFR).
    • If albumin is the predominant component, persistent proteinuria suggests renal disease, even in the absence of decreased glomerular filtration rate, hypertension, or other abnormal findings on urinalysis.
    • 24-hour urine collection is time consuming, inconvenient for patients, and subject to collection error. The Urinary Protein Excretion Estimation avoids these problems without sacrificing accuracy, by using a single urine sample.
    • Proteinuria is an independent risk factor for cardiovascular and renal disease, and predicts end organ damage. Detecting an increase in protein excretion has both diagnostic and prognostic value in initial detection and confirmation of renal disease.
    • Quantifying proteinuria can also help assess effectiveness of therapy and progression of disease.
    mg/dL
    mg/dL

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Jay M. Ginsberg

    About the Creator

    Jay M. Ginsberg, MD is a practicing nephrologist in Connecticut. Dr. Ginsberg graduated from Jefferson Medical College of Thomas Jefferson University in 1977 and has been in practice for 40 years. He completed a residency at Rhode Island Hospital and also specializes in internal medicine.

    To view Dr. Jay M. Ginsberg's publications, visit PubMed

    Are you Dr. Jay M. Ginsberg? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    Reviewed By
    • George Neiderman, MD
    About the Creator
    Dr. Jay M. Ginsberg
    Are you Dr. Jay M. Ginsberg?
    Content Contributors
    Reviewed By
    • George Neiderman, MD