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    Patent Pending

    Urinary Protein Excretion Estimation

    Quantifies 24-hour proteinuria with protein/creatinine ratio from a single urine sample.
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    BEFORE USE

    Avoid using overnight or first morning void as urine sample.

    When to Use
    Pearls/Pitfalls
    Why Use
    mg/dL
    mg/dL
    About the Creator
    Dr. Jay M. Ginsberg
    Content Contributors
    • Chetana Pendkar, MBBS
    • George Neiderman, MD

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    • UPEE >3.5 g per day in adults is associated with nephrotic syndrome.
    • Decrease in protein excretion to less than 2 g per day, either in response to therapy or spontaneously, is associated with improved long-term prognosis.

    Management

    • Patients with persistent low-grade proteinuria unrelated to decreased kidney function or a systemic disease typically have no long-term complications, even if untreated.
    • Many nephrologists use an antihypertensive drug, such as an angiotensin-converting enzyme (ACE) inhibitor, to reduce or eliminate proteinuria.
    • Patients with low-grade proteinuria should be evaluated yearly to make sure it is not getting worse and that kidney function is stable.
    Content Contributors
    • Chetana Pendkar, MBBS
    • George Neiderman, MD