Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

    Disease

    Select...

    Specialty

    Select...

    Chief Complaint

    Select...

    Organ System

    Select...

    Patent Pending

    Benzodiazepine Conversion Calculator

    Provides equivalents between different benzodiazepines.
    Favorite

    IMPORTANT

    This calculator should be used as a reference for oral benzodiazepine conversions. Equipotent benzodiazepine doses are reported as ranges due to paucity of literature supporting exact conversions, thus reported ranges are based on expert opinion and clinical experience published in psychiatric literature.

    INSTRUCTIONS

    Do not use to calculate initial dose for a benzo-naïve patient.

    When to Use
    Pearls/Pitfalls

    Intended for use when interchanging benzodiazepines and should not be used to help calculate an initial dose for a benzodiazepine naïve patient.

    • Durations of action:

      • Very short acting: <6 hours.

      • Short acting: 6-12 hours (ALPRAZolam, oxazepam, triazolam).

      • Intermediate acting: 12-24 hours (LORazepam, temazepam).

      • Long acting: >24 hours (chlordiazePOXIDE, diazePAM, clonazePAM).

    • This calculator does not account for age, organ function, and inter-patient variability that may alter the pharmacokinetics, peak effect, and duration of action.

    • Selecting doses on the lower end of the reported range may result in lower risk of unwanted oversedation.

    • Dosing conversions may not be adequate when treating such conditions as status epilepticus or alcohol withdrawal. Disease-state specific guidelines should be utilized.  

    ALPRAZolam (Xanax)
    ChlordiazePOXIDE (Librium)
    DiazePAM (Valium)
    ClonazePAM (KlonoPIN)
    LORazepam (Ativan)
    Oxazepam (Serax)
    Temazepam (Restoril)
    Triazolam (Halcion)
    mg
    ALPRAZolam (Xanax)
    ChlordiazePOXIDE (Librium)
    DiazePAM (Valium)
    ClonazePAM (KlonoPIN)
    LORazepam (Ativan)
    Oxazepam (Serax)
    Temazepam (Restoril)
    Triazolam (Halcion)

    Result:

    Please fill out required fields.

    Next Steps
    Evidence

    Advice

    Abrupt discontinuation of benzodiazepines should be avoided as this can precipitate withdrawal symptoms, including severe agitation and seizure activity.

    Content Contributors
    • Jenny L. Koehl, PharmD
    Reviewed By
    • Bryan D. Hayes, PharmD
    Content Contributors
    • Jenny L. Koehl, PharmD
    Reviewed By
    • Bryan D. Hayes, PharmD