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    Patent Pending

    Blood Volume Calculation

    Calculates total blood volume, red blood cell volume, and plasma volume.
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    When to Use
    Pearls/Pitfalls

    Use when blood volumes are needed (e.g. RBC exchange, plasma exchange, coagulation factor drug dosing, RhIG dosing calculations).

    Total blood volume is calculated using Nadler’s equation.

    Preterm neonate
    Term neonate
    Infant aged 1-4 months
    Child <25 kg (55 lbs)
    Child ≥25 kg (55 lbs) or adult
    %

    Result:

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    Evidence
    Creator Insights

    Advice

    If dosing for RBC exchange, use in conjunction with Sickle Cell RBC Exchange Volume.

    Formula

    Total blood volume, L (adults and children ≥25 kg)

    • Male = [ 0.3669 × (height, m)3 + 0.03219 × (weight, kg) + 0.6041 ] 
    • Female = [ 0.3561 × (height, m)3 + 0.03308 × (weight, kg) + 0.1833 ]

    Total blood volume, mL (neonates and children <25 kg) = weight, kg × Y, where Y is as follows:

    • Preterm neonate: 100 mL/kg
    • Term neonate: 85 mL/kg
    • Infant aged 1-4 months: 75 mL/kg
    • Child <25 kg: 70 mL/kg

    RBC volume, mL = total blood volume, mL × hematocrit / 100

    Plasma volume, mL = total blood volume, mL × ( 1 – hematocrit / 100 )

    Example: adult male, height = 180 cm, weight = 70 kg, Hct = 25%

    • Total blood volume, L
      • = [ 0.3669 × (height, m)3 + 0.03219 × (weight, kg) + 0.6041 ]
      • = [ 0.3669 × (180 / 100)3 + 0.03219 × (70) + 0.6041 ]
      • = 2.1398 + 2.2533 + 0.6041
      • = 5.0 L (4,997 mL)
    • Red blood cell volume, mL
      • = (4,997 mL) × (25% / 100)
      • = 4,997 mL × 0.25
      • = 1,249 mL
    • Plasma volume, mL
      • = 4,997 mL × [1 - (25% / 100)]
      • = 4,997 mL × 0.75
      • = 3,748 mL
    Dr. Samuel B. Nadler

    About the Creator

    Samuel B. Nadler, MD, (d. 1969) was the first head of the biophysics and nuclear medicine department at Touro Infirmary, later named the Nadler-Bloch Nuclear Medicine Department. He also served as the fifth president of the Southwestern Chapter of the Society of Nuclear Medicine and Molecular Imaging (SWC-SNMMI). Dr. Nadler is best known for his work with radioactive iodine and the thyroid.

    To view Dr. Samuel B. Nadler's publications, visit PubMed

    Content Contributors
    About the Creator
    Dr. Samuel B. Nadler
    Content Contributors