Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2019;50(12).

Jauch ED, et al. Guidelines for the early management of patients with acute ischemic stroke: A Guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013; 44: 870-947.

De Silva DA, Manzano JJ, Chang HM, Wong MC. Reconsidering recent myocardial infarction as a contraindication for IV stroke thrombolysis. Neurology. 2011 May 24;76(21):1838-40.

Selim M, Kumar S, Fink J, Schlaug G, Caplan LR, Linfante I. Seizure at stroke onset: should it be an absolute contraindication to thrombolysis? Cerebrovasc Dis. 2002;14(1):54-7.

Fugate JE, Rabinstein AA. Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke. Neurohospitalist. 2015;5(3):110-21.

Demaerschalk BM, et al. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2016 Feb;47(2):581-641.

Adams HP, et. al. Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients With Acute Ischemic Stroke: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. Circulation. 1996;94:1167-1174.

Dr. Edward C. Jauch

tPA Contraindications for Ischemic Stroke

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diagnosis

symptom_onset

hemorrhage

sub_hemorrhage

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hypertension

hist_hemorr

malformation

bleeding

endocarditis

diathesis

glucose

neoplasm

gi_malignancy

gi_hem

intra_surgery

arch

minor_stroke

surgery

gastro

seizure

art_puncture

lumb_puncture

pericarditis

pregnancy

age_80

stroke

anticoagulant

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multi_infarction

Assesses inclusion/exclusion criteria for tPA in acute ischemic stroke patients.

Inclusion and exclusion criteria for tPA.

tPA Contraindications

Daniel Runde, MD, is currently the assistant residency director and an assistant professor of emergency medicine at the University of Iowa Hospitals and Clinics. He received his medical degree at the University of Iowa Carver College of Medicine and completed residency in emergency medicine at St. Luke’s-Roosevelt Hospital Center in New York. He recently finished his Medical Education Fellowship at the department of emergency medicine at Harbor-UCLA. Dr. Runde is interested in evidence-based medicine with a focus on patient-important clinical outcomes, CT utilization in the emergency department and education and evaluation in medical education. Currently, he is in the process of obtaining a Masters in Medical Education through the Office of Consultation and Research in Medical Education at the University of Iowa Hospitals and Clinics.

Daniel Runde, MD

tPA Contraindications provide inclusion/exclusion criteria when deciding to use tPA on a patient with acute ischemic stroke.

NIH Stroke Scale (NIHSS)

tPA Dosing for Stroke Calculator

Intracerebral Hemorrhage (ICH) Score

The American Academy of Pediatrics (AAP) focuses on the health, safety, and well-being of infants, children, and young adults. With about 67,000 members, including pediatricians, medical subspecialists, and surgical specialists, the AAP supports optimal care. Over 45,000 members are board-certified Fellows of the AAP (FAAP). Its mission is to promote children's health and well-being while supporting members' professional needs.

American Academy of Pediatrics (AAP)

The American Association for Physician Leadership&reg; (AAPL) is the world&rsquo;s oldest and largest professional association dedicated solely to maximizing physician leadership.&nbsp;From the moment physicians begin their leadership journey through the time they are seasoned leaders, AAPL provides education and training, resources and tools, and content and experiences needed to close gaps between hands-on clinical care, organization system improvements and optimized business outcomes.

American Association for Physician Leadership (AAPL)

American Association for the Study of Liver Diseases

The American College of Emergency Physicians (ACEP) represents more than 38,000 emergency physicians, emergency medicine residents and medical students. ACEP promotes the highest quality of emergency care and is the leading advocate for emergency physicians and their patients, and the public. Members may earn up to 850 continuing medical education hours every year through ACEP&rsquo;s robust catalog of peer-reviewed publications and on-demand courses presented by world-renowned emergency medicine experts.

American College Of Emergency Physicians

The American College of Gastroenterology (ACG) supports clinicians in delivering high-quality, evidence-based care to gastroenterology patients. Its mission is to advance care for those with gastrointestinal disorders through excellence, innovation, and advocacy. ACG provides members with up-to-date scientific information through annual meetings, the American Journal of Gastroenterology, training courses, and research grants, focusing on digestive health and GI disorder treatments.

American College of Gastroenterology

American College of Rheumatology

The American Gastroenterological Association (AGA), founded in 1897, provides leadership and education to over 16,000 members worldwide, all dedicated to advancing gastroenterology. The AGA&rsquo;s mission is to empower clinicians and researchers to improve digestive health through clinical guidance, practice resources, and peer-reviewed research. Key journals include Gastroenterology, Clinical Gastroenterology and Hepatology, Cellular and Molecular Gastroenterology and Hepatology, and others.

American Gastroenterological Association

American Heart Association

American Urological Association

EB Medicine is the premier provider of evidence-based clinical content and CME resources for emergency medicine practitioners.

EB Medicine

MDCalc CME

Postgraduate Institute for Medicine

The Rome Foundation is a nonprofit organization dedicated to advancing the diagnosis and treatment of Disorders of Gut-Brain Interaction (DGBI), also known as functional gastrointestinal disorders. Its mission is to improve the lives of people with DGBI. For over 30 years, the Rome Foundation has worked with scientists and clinicians worldwide to classify and assess GI function and dysfunction, creating symptom-based criteria used in clinical trials and daily practice to guide diagnosis and treatment.

The ROME Foundation

Listen to the VACO co-creators break down how to use VACO\, what it does\, and what it doesn’t.

Calc Function