Powers WJ, Rabinstein AA, Ackerson T, et al. Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke. 2019;50(12).

Jauch ED, et al. Guidelines for the early management of patients with acute ischemic stroke: A Guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013; 44: 870-947.

De Silva DA, Manzano JJ, Chang HM, Wong MC. Reconsidering recent myocardial infarction as a contraindication for IV stroke thrombolysis. Neurology. 2011 May 24;76(21):1838-40.

Selim M, Kumar S, Fink J, Schlaug G, Caplan LR, Linfante I. Seizure at stroke onset: should it be an absolute contraindication to thrombolysis? Cerebrovasc Dis. 2002;14(1):54-7.

Fugate JE, Rabinstein AA. Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke. Neurohospitalist. 2015;5(3):110-21.

Demaerschalk BM, et al. Scientific Rationale for the Inclusion and Exclusion Criteria for Intravenous Alteplase in Acute Ischemic Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2016 Feb;47(2):581-641.

Adams HP, et. al. Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients With Acute Ischemic Stroke: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association. Circulation. 1996;94:1167-1174.

Dr. Edward C. Jauch

tPA Contraindications for Ischemic Stroke

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diagnosis

symptom_onset

hemorrhage

sub_hemorrhage

surg_trauma_stroke

hypertension

hist_hemorr

malformation

bleeding

endocarditis

diathesis

glucose

minor_stroke

surgery

gastro

seizure

art_puncture

lumb_puncture

pericarditis

pregnancy

age_80

stroke

anticoagulant

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multi_infarction

Provides inclusion/exclusion criteria when deciding to use tPA on a patient with acute ischemic stroke.

Inclusion &amp; exclusion criteria for tPA.

tPA Contraindications

Daniel Runde, MD, is currently the assistant residency director and an assistant professor of emergency medicine at the University of Iowa Hospitals and Clinics. He received his medical degree at the University of Iowa Carver College of Medicine and completed residency in emergency medicine at St. Luke’s-Roosevelt Hospital Center in New York. He recently finished his Medical Education Fellowship at the department of emergency medicine at Harbor-UCLA. Dr. Runde is interested in evidence-based medicine with a focus on patient-important clinical outcomes, CT utilization in the emergency department and education and evaluation in medical education. Currently, he is in the process of obtaining a Masters in Medical Education through the Office of Consultation and Research in Medical Education at the University of Iowa Hospitals and Clinics.

Daniel Runde, MD

tPA Contraindications provide inclusion/exclusion criteria when deciding to use tPA on a patient with acute ischemic stroke.

NIH Stroke Scale (NIHSS)

tPA Dosing for Stroke Calculator

Intracerebral Hemorrhage (ICH) Score

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