Reynolds Risk Score for Cardiovascular Risk in Women

Use the Reynolds Risk Score as one component of primary prevention risk assessment. It may be most useful when traditional risk estimates are uncertain and information on hsCRP or parental history of premature MI is available.

Risk estimates should be interpreted in the context of clinical judgement and contemporary risk stratification methods (e.g., PREVENT risk score) and guideline recommendations (e.g., 2026 ACC/AHA lipid guidelines) for lipid lowering therapy eligibility determination.

• Score should not be used in isolation to determine statin therapy or other preventive treatment. Incorporate current prevention guidelines, clinician-patient discussion, comorbidities, life expectancy, medication tolerance, and patient preferences.
• Do not apply to patients with established ASCVD, and use caution when applying to populations underrepresented in the derivation cohort.