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    Naloxone Drip Dosing

    Doses naloxone for acute opioid overdose.


    This dosing tool is intended to assist with calculation, not to provide comprehensive or definitive drug information. Always double-check dosing of any drug and consult a pharmacist when necessary.


    Use in patients with respiratory or central nervous system depression from opioid analgesic overdose.

    When to Use
    Why Use
    • Respiratory or CNS depression from opioid analgesic overdose.
    • Respiratory depression responsive to naloxone administration.
    • Respiratory depression requiring more than one IV dose of naloxone.
    • Goal is to maintain the same level of reversal following initial naloxone bolus.
    • Bolus dose necessary to reverse the respiratory depressant effects of the opioid overdose should be determined clinically.
    • Bolus dose = total dose required in the first hour.

    The half-life of naloxone is between 30 and 100 minutes. Because the duration of action of most available opioids exceeds that of naloxone, repeated administration or a continuous IV infusion may be required to prevent recurrence of respiratory depression.


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    Creator Insights
    Dr. Lewis Goldfrank

    About the Creator

    Lewis Goldfrank, MD, FACEP, FAAEM, FAACT, FACMT, FACP, is the Herbert W. Adams Professor of Emergency Medicine at New York University. He is also the medical director of the New York City Poison Control Center. Dr. Goldfrank is perhaps best known as author and editor of the primary toxicology reference Goldfrank's Toxicologic Emergencies.

    To view Dr. Lewis Goldfrank's publications, visit PubMed

    Are you Dr. Lewis Goldfrank? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
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