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    Charlson Comorbidity Index (CCI)

    Predicts 10-year survival in patients with multiple comorbidities.
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    Formula

    Addition of the selected points:

    1 point

    Myocardial infarction

    Congestive heart failure

    Peripheral vascular disease

    Cerebrovascular disease

    Dementia

    Chronic pulmonary disease

    Connective tissue disease

    Ulcer disease

    Mild liver disease

    Diabetes

    2 points

    Hemiplegia

    Moderate or severe renal disease

    Diabetes with end organ damage

    Any tumor

    Leukemia

    Lymphoma

    3 points

    Moderate or severe liver disease

    6 points

    Metastatic solid tumor

    AIDS*

    Plus 1 point for every decade age 50 years and over, maximum 4 points.

    10-year survival = 0.983^(eCCI × 0.9), where CCI = Charlson Comorbidity Index.

    *Note: This data is from the original Charlson study in 1987, before the widespread availability of effective antiretroviral therapy. We are not aware of any re-evaluations  of the CCI using more recent data.

    Literature

    Dr. Mary Charlson

    About the Creator

    Mary Charlson, MD, is the William Foley Professor of Medicine, Chief of General Internal Medicine and the Program Chairperson for the Master of Science Program in Clinical Epidemiology and Health Services Research at Weill Cornell Medical College. She is also a clinical epidemiologist and methodologist. Dr. Charlson has also developed new methods of improving prognostic stratification in acute and chronic illness.

    To view Dr. Mary Charlson's publications, visit PubMed