Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

    Disease

    Select...

    Specialty

    Select...

    Chief Complaint

    Select...

    Organ System

    Select...

    Patent Pending

    CKD-EPI Equations for Glomerular Filtration Rate (GFR)

    Estimates GFR based on serum creatinine, serum cystatin C, or both.
    When to Use
    Pearls/Pitfalls
    Why Use
    • Patients with chronic kidney disease (not acute), to measure renal function.
    • CKD-EPI Cystatin C is preferred in cirrhotics and other patients with low muscle mass.
    • CKD-EPI Creatinine can be used in settings where cystatin C is not available.  
    • Creatinine-based estimates of kidney function by glomerular filtration rate (GFR) are less accurate in certain populations including diabetics with high GFR, pregnant women, those with unusual body mass (obese, severely malnourished, amputees, paraplegics, etc).
    • Cystatin C-based estimates vary based on factors still being studied including age, race and gender.
    • Creatinine estimates alone are more accurate than cystatin C-based estimates.
    • Used together, creatinine and cystatin C estimates are more accurate than using either alone.

    The CKD-EPI equation performs superiorly to the MDRD Equation in patients with normal or mildly reduced estimated GFR (eGFR), and just as well in patients with less than normal eGFR.

    CKD-EPI Creatinine
    CKD-EPI Cystatin C
    CKD-EPI Creatinine–Cystatin C
    Female
    Male
    years

    Result:

    Please fill out required fields.

    Next Steps
    Evidence
    Creator Insights
    Dr. Andrew S. Levey

    About the Creator

    Andrew S. Levey, MD, is the chief of the nephrology division at Tufts Medical Center and the Dr. Gerald J. and Dorothy R. Friedman Professor at Tufts University School of Medicine. His clinical interests include chronic kidney disease (CKD), diabetic kidney disease, and systemic lupus erythematosus. Dr. Levey’s research focuses on laboratory measures to estimate kidney function, new therapies, and the development of clinical practice guidelines for CKD.

    To view Dr. Andrew S. Levey's publications, visit PubMed

    Are you Dr. Andrew S. Levey? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    • Omar Aziz, MD
    About the Creator
    Dr. Andrew S. Levey
    Are you Dr. Andrew S. Levey?
    Content Contributors
    • Omar Aziz, MD