CKD-EPI Equations for Glomerular Filtration Rate (GFR)
The 2021 CKD-EPI equation is now the recommended standard. This version does not include race, as do the 2009 and 2012 CKD-EPI creatinine and creatinine-cystatin C equations. See here for more on our approach to addressing race and bias on MDCalc.
With the 2021 equation, for the same creatinine value, the 2021 equation will estimate a lower GFR for Black patients and a higher GFR for non-Black patients.
For use in patients with stable kidney function. While the combined creatinine and cystatin C equation can add accuracy, cystatin c is not available in all laboratories and the creatinine-based equation is adequate for many clinical purposes.
2021 CKD-EPI creatinine is currently recommended by the ASN and NKF for GFR reporting in the United States.
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- Omar Aziz, MD
- Evan Zeitler, MD