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    CKD-EPI Equations for Glomerular Filtration Rate (GFR)

    Estimates GFR based on serum creatinine, serum cystatin C, or both.
    When to Use
    Why Use
    • Patients with chronic kidney disease (not acute), to measure renal function.
    • CKD-EPI Cystatin C is preferred in cirrhotics and other patients with low muscle mass.
    • CKD-EPI Creatinine can be used in settings where cystatin C is not available.  
    • Creatinine-based estimates of kidney function by glomerular filtration rate (GFR) are less accurate in certain populations including diabetics with high GFR, pregnant women, those with unusual body mass (obese, severely malnourished, amputees, paraplegics, etc).
    • Cystatin C-based estimates vary based on factors still being studied including age, race and gender.
    • Creatinine estimates alone are more accurate than cystatin C-based estimates.
    • Used together, creatinine and cystatin C estimates are more accurate than using either alone.

    The CKD-EPI equation performs superiorly to the MDRD Equation in patients with normal or mildly reduced estimated GFR (eGFR), and just as well in patients with less than normal eGFR.

    CKD-EPI Creatinine
    CKD-EPI Cystatin C
    CKD-EPI Creatinine–Cystatin C


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    Creator Insights
    Dr. Andrew S. Levey

    About the Creator

    Andrew S. Levey, MD, is the chief of the nephrology division at Tufts Medical Center and the Dr. Gerald J. and Dorothy R. Friedman Professor at Tufts University School of Medicine. His clinical interests include chronic kidney disease (CKD), diabetic kidney disease, and systemic lupus erythematosus. Dr. Levey’s research focuses on laboratory measures to estimate kidney function, new therapies, and the development of clinical practice guidelines for CKD.

    To view Dr. Andrew S. Levey's publications, visit PubMed

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    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
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    Dr. Andrew S. Levey
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