D'Amico Risk Classification for Prostate Cancer
Developed in 1998, estimates risk of prostate cancer recurrence (low, medium or high) from PSA level, Gleason Score, and tumor stage. May be less accurate in men with multiple risk factors.
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With changing treatment patterns, there is a large variation on how to treat different risk groups. Low risk patients seem to do well with many treatment modalities. Intermediate risk patients are a very variable group, where further understanding of risk of cancer “beyond the gland” may be necessary to guide treatment. High risk groups often do best with a multimodal treatment approach.
Risk calculated by combination of above factors.
Facts & Figures
Original/Primary ReferenceD'Amico AV, Whittington R, Malkowicz S, et al. Biochemical Outcome After Radical Prostatectomy, External Beam Radiation Therapy, or Interstitial Radiation Therapy for Clinically Localized Prostate Cancer. JAMA.1998;280(11):969-974. doi:10.1001/jama.280.11.969.
ValidationBoorjian SA, Karnes RJ, Rangel LJ. Mayo Clinic validation of the D'amico risk group classification for predicting survival following radical prostatectomy. J Urol. 2008 Apr;179(4):1354-60; discussion 1360-1. Epub 2008 Mar 4.Hernandez DJ, Nielsen ME, Han M. Contemporary evaluation of the D'amico risk classification of prostate cancer. Urology. 2007 Nov;70(5):931-5.
Other ReferencesRodrigues G, Warde P, Pickles T, et al. Pre-treatment risk stratification of prostate cancer patients: A critical review. Canadian Urological Association Journal. 2012;6(2):121-127. doi:10.5489/cuaj.11085.Moul JW. The Evolving Definition of Advanced Prostate Cancer. Reviews in Urology. 2004;6(Suppl 8):S10-S17
About the Creator
Anthony D'Amico, MD, PhD, is professor of radiation oncology at Harvard Medical School. He is also chief of the Division of Genitourinary Radiation Oncology at Brigham and Women's Hospital and Dana-Farber Cancer Institute. Dr. D'Amico's notable research involves the detection, staging, and treatment of prostate cancer, with over 140 peer-reviewed publications and four co-edited textbooks.
To view Dr. Anthony D'Amico's publications, visit PubMed