Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
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    Patent Pending

    EUTOS Score for Chronic Myelogenous Leukemia (CML)

    Predicts outcomes after CML treatments, specifically adjusted for tyrosine kinase treatments.
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    INSTRUCTIONS

    Use in newly-diagnosed patients before starting therapy.

    When to Use
    Pearls/Pitfalls
    Why Use

    Newly-diagnosed CML patients prior to discussions regarding prognosis and treatment options.

    • The EUTOS (European Treatment and Outcome Study) Score predicts survival and can also be used to predict the probability of complete cytogenetic response at 18 months.
    • Has better predictive value than the Sokal Score.
    • Spleen size estimation is subjective; however, that subjectivity is also included in other CML prognostic scores.
    • Developed in patients treated with imatinib, so outcomes may not apply with newer generation therapies.
    • Estimates response to therapy to, and survival on, the reference TKI (tyrosine kinase inhibitor) imatinib.
    • Only requires two values, which can be clinically detected prior to completing a bone marrow biopsy.
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    Result:

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    Next Steps
    Evidence
    Creator Insights

    Management

    Though there is no broad consensus on management, a conservative strategy is to treat low-risk patients with imatinib and reserve newer-generation TKIs for high risk patients.

    Critical Actions

    Can only be applied to a newly-diagnosed patient before starting therapy.

    Content Contributors
    Reviewed By
    • Michael Mauro, MD
    About the Creator
    Dr. Joerg Hasford
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    Content Contributors
    Reviewed By
    • Michael Mauro, MD