Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





    Chief Complaint


    Organ System


    Patent Pending

    Expanded Disability Status Scale (EDSS) / Functional Systems Score (FSS)

    Describes severity of disability in patients with MS.
    • The Expanded Disability Status Scale (EDSS) works together with the Functional Systems Scale (FSS) to measure MS disease progression.
    • The EDSS assesses the disability status of MS patients on a scale from 0 to 10.
    • Scores from 0 to 3.5 are determined by deficits in eight Functional Systems (FS) in patients who do not have any impairment of ambulation.
    • Scores from 4.0 to 10.0 are determined both by ambulatory ability and FS deficits, which typically correlate with each other.
    • Some providers use only the ambulatory score to determine the overall EDSS score between 4.0 and 10.0.
    • In situations when there is subjectivity and FS deficits do not correspond to a specific EDSS level, a range is provided.
    Ambulation Scoring
    Functional Systems


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    Creator Insights


    Use to measure progression of disease in MS patients.

    Use to compare outcomes in MS clinical trials.


    EDSS: Points assigned based on level of disability.

    FSS: Addition of selected points within body system.

    Facts & Figures

    Score of 1.0 to 4.5 -- Normal ambulation.

    Score of 5.0 to 9.5 -- Impaired ambulation.

    Dr. John F. Kurtzke

    About the Creator

    John F. Kurtzke, MD, (d. 2015) was professor emeritus of neurology at Georgetown University. He was a leading expert in the study of multiple sclerosis (MS) and a contributor in the creation of the field of neuroepidemiology. Dr. Kurtzke authored over 200 peer-reviewed articles and received multiple awards for MS research including the Charcot Award from the MS International Federation.

    To view Dr. John F. Kurtzke's publications, visit PubMed