Higher GAP stages and scores correspond to a greater need for transplantation and other treatments.
Addition of assigned points.
The GAP Score stands for the “Gender, Age, and Physiology score.”
- Gender and Age each have one associated criterion.
- Physiology has two associated criteria (FVC and DLCO).
Facts & Figures
GAP staging for IPF:
*The GAP index is more sensitive, but less specific, than the the du Bois Score for predicting mortality.
Original/Primary ReferenceLey B, Ryerson CJ, Vittinghoff E, Ryu JH, Tomassetti S, Lee JS, et al. A multidimensional index and staging system for idiopathic pulmonary fibrosis. Ann Intern Med. 2012;156:684–91. doi: 10.7326/0003-4819-156-10-201205150-00004.
ValidationKim E, Choi S, Lee J, et al. Validation Of The Gap Score In Korean Patients With Idiopathic Pulmonary Fibrosis. Chest 2015;147(2):430-437. doi:10.1378/chest.14-0453.
Other ReferencesLey B, Bradford WZ, Weycker D, Vittinghoff E, du Bois RM, Collard HR. Unified baseline and longitudinal mortality prediction in idiopathic pulmonary fibrosis. Eur Respir J. 2015;45:1374–81. doi: 10.1183/09031936.00146314Wilkie MEM, Chalmers JD, Smith RP, Schembri S. Asthma outcomes: P134 Comparison of Two Prognostic Tools For Identifying High Risk Patients with Idiopathic Pulmonary Fibrosis. Thorax 2012;67:Suppl 2 A120 doi:10.1136/thoraxjnl-2012-202678.417
About the Creator
Brett Ley, MD, is a clinical fellow in the pulmonology department at UCSF School of Medicine. He is an active researcher on lung pathology with 2 active NIH grants and multiple published and peer reviewed papers. Dr. Ley’s research interests include interstitial lung diseases and prediction modeling.
To view Dr. Brett Ley's publications, visit PubMed