Calc Function

  • Diagnosis
  • Rule Out
  • Prognosis
  • Formula
  • Treatment
  • Algorithm
  • Disease
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    Specialty
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    Chief Complaint
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    Organ System
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    Treatment of Non-Metastatic Muscle-Invasive Bladder Cancer

    Based on guidelines from AUA, ASCO, ASTRO, and SUO.

    Initial Evaluation and Counseling

    Evaluation

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    Clinical principle

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    Clinical principle

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    Clinical principle

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    Clinical principle

    Counseling

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    Clinical principle

    Treatment

    Neoadjuvant/Adjuvant Chemotherapy

    Strong recommendation
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    Grade B quality evidence

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    Moderate recommendation
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    Grade C quality evidence

    Radical Cystectomy

    Strong recommendation
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    Grade B quality evidence

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    Clinical principle

    Moderate recommendation
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    Grade C quality evidence

    Urinary Diversion

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    Clinical principle

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    Clinical principle

    Perioperative Surgical Management

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    Strong recommendation
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    Grade B quality evidence

    Strong recommendation
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    Grade B quality evidence

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    Clinical principle

    Pelvic Lymphadenectomy

    Strong recommendation
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    Grade B quality evidence

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    Clinical principle

    Bladder Preserving Approaches

    Patient Selection

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    Clinical principle

    Strong recommendation
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    Grade C quality evidence

    Maximal TURBT and Partial Cystectomy

    Moderate recommendation
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    Grade C quality evidence

    Primary Radiation Therapy

    Strong recommendation
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    Grade C quality evidence

    Multi-Modal Bladder Preserving Therapy

    Strong recommendation
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    Grade B quality evidence

    Strong recommendation
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    Grade B quality evidence

    Strong recommendation
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    Grade C quality evidence

    Bladder Preserving Treatment Failure

    Strong recommendation
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    Grade C quality evidence

    Moderate recommendation
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    Grade C quality evidence

    Surveillance and Follow Up

    Imaging

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    Laboratory Values and Urine Markers

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    Patient Survivorship

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    Variant Histology

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    How strong is the AUA, ASCO, ASTRO, and SUO's recommendation?

    Strong recommendation
    An action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken because net benefit or net harm is substantial.
    Moderate recommendation
    An action should (benefits outweigh risks/burdens) or should not (risks/burdens outweigh benefits) be undertaken because net benefit or net harm is moderate.
    Conditional recommendation
    The evidence indicates that there is no apparent net benefit or harm or when the balance between benefits and risks/burden is unclear.
    Grade A quality evidence
    The benefits and risks/burdens appear balanced, and the best action depends on patient circumstances. Future research is unlikely to change confidence.
    Grade B quality evidence
    The benefits and risks/burdens appear balanced, and the best action depends on individual patient circumstances. Better evidence could change confidence.
    Grade C quality evidence
    There is uncertainty regarding the balance between benefits and risks/burdens, and alternative strategies may be equally reasonable. Better evidence is likely to change confidence.
    Clinical principle
    A statement about a component of clinical care that is widely agreed upon by urologists or other clinicians for which there may or may not be evidence in the medical literature.
    A statement, achieved by consensus of the Panel, that is based on members' clinical training, experience, knowledge, and judgment for which there is no evidence.