Calc Function

  • Diagnosis
  • Rule Out
  • Prognosis
  • Formula
  • Treatment
  • Algorithm
  • Disease
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    Specialty
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    Chief Complaint
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    Organ System
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    Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma (OPSCC)(beta)

    Based on guidelines from the American Society for Radiation Oncology, also endorsed by ASCO.

    Systemic Therapy and Definitive Radiotherapy

    Stages IVA and IVB

    Strong recommendation
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    High quality evidence

    Conditional recommendation
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    High quality evidence

    Conditional recommendation
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    Low quality evidence

    Strong recommendation
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    High quality evidence

    Strong recommendation
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    High quality evidence

    Stage III

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Stages I and II

    Strong recommendation
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    Low quality evidence

    Postoperative Radiotherapy

    Positive Margins and/or Extracapsular Nodal Extension

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Strong recommendation
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    Moderate quality evidence

    Strong recommendation
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    Moderate quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    Moderate quality evidence

    Strong recommendation
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    High quality evidence

    Intermediate-risk Pathologic Factors

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    Low quality evidence

    Conditional recommendation
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    Low quality evidence

    Conditional recommendation
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    Low quality evidence

    No Pathologic Risk Factors

    Conditional recommendation
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    Low quality evidence

    Induction Chemotherapy

    Induction Chemotherapy

    Strong recommendation
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    High quality evidence

    Dose, Fractionation, and Volume Regimens

    Definitive Nonsurgical Therapy

    Strong recommendation
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    Moderate quality evidence

    Strong recommendation
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    Low quality evidence

    Strong recommendation
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    High quality evidence

    Conditional recommendation
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    High quality evidence

    Conditional recommendation
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    High quality evidence

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Adjuvant Postoperative Radiotherapy

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    Strong recommendation
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    Moderate quality evidence

    Early T-stage Tonsillar Carcinoma

    Strong recommendation
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    Moderate quality evidence

    Conditional recommendation
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    Low quality evidence

    How strong is the ASCO's recommendation?

    Strong recommendation
    The panel was very confident that the benefits of the intervention clearly outweighed the harms.
    Conditional recommendation
    The evidence indicates that there is no apparent net benefit or harm or when the balance between benefits and risks/burden is unclear.
    High quality evidence
    We are very confident that the true effect lies close to that of the estimate of the effect.
    Moderate quality evidence
    We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
    Low quality evidence
    Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect.