Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm





    Chief Complaint


    Organ System


    Patent Pending

    Adjuvant Therapy for Resected Biliary Tract Cancer (beta)

    Based on guidelines from the American Society of Clinical Oncology.

    Strong recommendation
    Moderate recommendation
    Weak recommendation
    High quality evidence
    Intermediate quality evidence
    Low quality evidence
    Insufficient evidence


    Adjuvant Capecitabine Chemotherapy
    1. Patients with resected biliary tract cancer should be offered adjuvant capecitabine chemotherapy for a duration of 6 months.
    2. In the BILCAP (Adjuvant Capecitabine for Biliary Tract Cancer) phase III randomized controlled trial, capecitabine was delivered at a dose of 1,250 mg/m2 twice a day on treatment days 1 to 14 of a 3-week cycle for 24 weeks (eight cycles) [Qualifying statement].
    3. The Expert Panel agrees that the recommended dose of capecitabine may be determined by institutional and regional practices [Qualifying statement].
    1. Patients with extrahepatic cholangiocarcinoma or gallbladder cancer and a microscopically positive surgical margin resection (R1 resection) may be offered chemoradiotherapy.
    2. A shared decision-making approach is recommended, considering the risk of potential harm and potential for benefit associated with radiation therapy for patients with extrahepatic cholangiocarcinoma or gallbladder cancer [Qualifying statement].
    3. The Expert Panel notes that in the SWOG0809 prospective single-arm trial of chemoradiotherapy, radiation was delivered at a dose of 45 Gy to regional lymphatics and 54 to 59.4 Gy to the tumor bed. However, at this time, the evidence base is not sufficiently well developed to make a recommendation for optimal dosing of radiation therapy in the context of chemoradiation therapy [Qualifying statement].
    What do the icons mean?  
    Research PaperShroff RT, Kennedy EB, Bachini M, et al. Adjuvant Therapy for Resected Biliary Tract Cancer: ASCO Clinical Practice Guideline. J Clin Oncol. 2019;37(12):1015-1027.