HOMA-IR (Homeostatic Model Assessment for Insulin Resistance)
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The HOMA-IR score may be most useful for epidemiologic, population-based, and other group level assessments. In addition, optimal diagnostic cutoffs for IR-related conditions seem to vary considerably from one population or group to the next so care should be taken to customize cutoffs when using the score.
We are unaware of validated management algorithms using the HOMA-IR score.
The HOMA-IR score should not be used in patients on insulin, and studies have questioned its accuracy in those with impaired glucose tolerance, normal BMI, the elderly, and others.