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    Patent Pending

    Hypoglycemia Risk Score

    Predicts 12-month risk of hypoglycemic episodes in T2DM patients.
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    Pearls/Pitfalls
    Why Use
    • Developed based on electronic health record data to inform population management interventions and therefore may have limited application in individual patients.
    • Validated in two external cohorts, but has yet to be applied prospectively.
    • Iatrogenic hypoglycemia is a frequent adverse event in patients with type 2 diabetes, with 1 in 4 emergency hospitalizations for adverse drug events being related to hypoglycemia.
    • Helps identify highest risk patients, who might benefit from targeted interventions (e.g. simplified medication regimens, continuous glucose monitoring, addressing psychosocial and socioeconomic factors).
    0
    1-2
    ≥3

    Result:

    Please fill out required fields.

    Next Steps
    Evidence
    Creator Insights

    Advice

    High risk patients may benefit from targeted interventions (e.g. simplified medication regimens, continuous glucose monitoring, addressing psychosocial and socioeconomic factors).

    Formula

    Select option for each input and see Facts & Figures for interpretation:

    Input

    Options

    Hypoglycemia admissions*

    0

    1-2

    ≥3

    ED visits, last 12 months**

    <2

    ≥2

    --

    Insulin use

    No

    Yes

    --

    Sulfonylurea use

    No

    Yes

    --

    Severe or end-stage kidney disease (eGFR ≤29 by CKD-EPI Creatinine)

    No

    Yes

    --

    Age

    <77 years

    ≥77 years

    --

    *ED visit or hospital admission for hypoglycemia at any time.

    **For any reason.

    Facts & Figures

    Interpretation:

     

    Risk category

    12-month risk of hypoglycemia admission

    ≥3 previous hypoglycemia admissions, OR

    High

    >5%

    1-2 previous hypoglycemia admission(s) + insulin use

    0 previous hypoglycemia admissions + no insulin use + no sulfonylurea use, OR

    Low

    <1%

    0 previous hypoglycemia admissions + no insulin use + sulfonylurea use + age <77 years + no severe or end-stage kidney disease, OR

    0 previous hypoglycemia admissions + insulin use + age <77 years + <2 ED visits

    All other risk factor combinations

    Intermediate

    1-5%

    Dr. Andrew J. Karter

    About the Creator

    Andrew J. Karter, PhD, is a research scientist at Kaiser Permanente Northern California. He is also an adjunct professor in the department of general internal medicine at UCSF and affiliate professor in the department of epidemiology at the University of Washington. Dr. Karter's research interests are focused on diabetes and its complications, including impacts on care from medication adherence, literacy, provider communications, IT, and language barriers.

    To view Dr. Andrew J. Karter's publications, visit PubMed

    About the Creator
    Dr. Andrew J. Karter