Note: the Friedewald formula is known to be inaccurate at extremely high triglyceride and total cholesterol levels. If there is any question about accuracy of estimated LDL, a direct level should be measured.
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Patients with elevated cholesterol may have success with diet and exercise, however those with other cardiovascular risk factors may require medication to reduce levels significantly.
Latest LDL Guidelines (NCEP 2004 Update):
- “Very” High Risk: Guidelines suggest <70mg/dL may be a reasonable option, but data may suggest there is little incremental benefit to this extreme but with high associated cost
- High Risk (known CAD, known other atherosclerotic dz, diabetes, etc): <100 mg/dL
- Moderate Risk (>1 risk factor): <130 mg/dL
- Lower Risk (0-1 risk factors): <160 mg/dL