Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
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    Patent Pending

    LDL Calculated

    Calculates LDL based on total and HDL cholesterol and triglycerides.
    Favorite
    Pearls/Pitfalls
    Remember, triglycerides should only be calculated when fasting.
    mg/dL
    mg/dL
    mg/dL

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    Patients with elevated cholesterol may have success with diet and exercise, however those with other cardiovascular risk factors may require medication to reduce levels significantly.

    Latest LDL Guidelines (NCEP 2004 Update):

    • “Very” High Risk: Guidelines suggest <70mg/dL may be a reasonable option, but data may suggest there is little incremental benefit to this extreme but with high associated cost
    • High Risk (known CAD, known other atherosclerotic dz, diabetes, etc): <100 mg/dL
    • Moderate Risk (>1 risk factor): <130 mg/dL
    • Lower Risk (0-1 risk factors): <160 mg/dL

    Formula

    LDL Cholesterol = Total Cholesterol - HDL - (TG / 5)

    Facts & Figures

    Latest LDL Guidelines (NCEP 2004 Update):

    • “Very” High Risk: Guidelines suggest <70mg/dL may be a reasonable option, but data may suggest there is little incremental benefit to this extreme but with high associated cost
    • High Risk (known CAD, known other atherosclerotic dz, diabetes, etc): <100 mg/dL
    • Moderate Risk (>1 risk factor): <130 mg/dL
    • Lower Risk (0-1 risk factors): <160 mg/dL

    Risk Factors:

    • Diabetes
    • Cigarette smoking
    • HTN (BP 140/90 mm Hg or on antihypertensive medication)
    • Low HDL cholesterol ( <40 mg/dL)
    • Family history of premature CAD (CAD in male first-degree relative, or father less than 55, or female first-degree relative or mother less than 65)

    Literature

    Original/Primary Reference

    Research PaperNCEP 2004 update to LDL Guidelines
    Dr. William Friedewald

    About the Creator

    William Friedewald, MD, is professor of biostatistics and epidemiology at the Columbia University Medical Center. His research focuses on mainly cardiovascular disease though he has begun to research how diabetes can affect traumatic brain injury.

    To view Dr. William Friedewald's publications, visit PubMed