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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    McDonald Criteria for Multiple Sclerosis (2017 Revision)

    Diagnoses multiple sclerosis.
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    INSTRUCTIONS

    Changes from the 2010 McDonald Criteria:

    1. Presence of CSF-specific oligoclonal bands may now substitute for dissemination in time (DIT) even if baseline MRI findings do not meet DIT criteria.

    2. In patients with brainstem or spinal cord attacks, symptomatic lesions may now be included as MRI evidence of dissemination in space (DIS) or DIT.

    3. Cortical lesions may now fulfill MRI criteria for DIS (in addition to juxtacortical lesions).

    When to Use
    Pearls/Pitfalls

    Patients with suspected MS who have undergone MRI.

    • Developed for patients with a typical clinically isolated syndrome deemed unlikely to have other diagnoses, NOT to differentiate MS from other conditions.
    • These criteria may help differentiate relapsing-remitting MS from other clinically isolated syndromes that may mimic it.
    Clinical attacks

    Must have ≥1 clinical attack

    ≥2
    1
    Lesions

    Must have ≥1 lesion

    ≥2
    1

    Diagnostic Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    Threshold for additional testing (i.e., spinal cord MRI or CSF examination) should be low, according to the international panel that developed these criteria.

    About the Creator
    Dr. Alan J. Thompson
    Are you Dr. Alan J. Thompson?