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    Patent Pending

    MDRD GFR Equation

    Estimates glomerular filtration rate based on creatinine and patient characteristics.

    IMPORTANT

    This calculator includes inputs based on race, which may or may not provide better estimates, so we have decided to make race optional. See here for more on our approach to addressing race and bias on MDCalc.

    For the same creatinine value, this calculator estimates a higher GFR for Black patients.

    INSTRUCTIONS

    Only for chronic kidney disease (CKD); not accurate for acute renal failure. This calculator uses the 4-variable equation from Levey 2006, which relied on a standardized creatinine assay.

    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with chronic kidney disease, to estimate kidney function.

    • The MDRD equation cannot be used for acute renal failure. It is only useful in estimating glomerular filtration rate (GFR) in stable chronic kidney disease.
    • Despite improvements to the MDRD equation, it tends to significantly underestimate measured GFR.
    • Underestimation of GFR is particularly significant in patients with a GFR > 60 ml/min/m2; 29% in healthy patients undergoing evaluation for kidney donation.

    Noninvasively estimates the measured GFR to determine degree or presence of decreased kidney function. The MDRD equation performs equally to the newer CKD-EPI Equation in patients with GFR of < 60 ml/min/1.73m2. Performs superiorly to the Cockcroft-Gault Equation.

    Female
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    years
    mg/dL
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    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Andrew S. Levey

    About the Creator

    Andrew S. Levey, MD, is a professor of medicine and Dr. Gerald J. and Dorothy R. Friedman professor emeritus at Tufts University School of Medicine in Massachusetts. He is also chief emeritus of the William B. Schwartz Division of Nephrology at Tufts. For more than 20 years, he has been at the forefront of the development of equations to estimate glomerular filtration rate from serum creatinine, cystatin C and novel filtration markers using large databases, including the widely-used Modification of Diet in Renal Disease (MDRD) Study and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Dr. Levey’s research interests include measurement and estimation of kidney function, epidemiology and clinical trials in chronic kidney disease.

    To view Dr. Andrew S. Levey's publications, visit PubMed

    Are you Dr. Andrew S. Levey? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    • Evan Zeitler, MD
    About the Creator
    Dr. Andrew S. Levey
    Are you Dr. Andrew S. Levey?
    Content Contributors
    • Evan Zeitler, MD