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    Patent Pending

    Mekhail Extension of the Motzer Score

    Predicts metastatic renal cell carcinoma survival, more accurately than the Motzer Score.
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    When to Use
    Pearls/Pitfalls
    Why Use

    Patients with mRCC being considered for clinical trial enrollment.

    This score placed clinical trial subjects from the 1970s-1990s with metastatic renal cell carcinoma (mRCC) into three groups with “poor,” “intermediate,” and “favorable” survival. There are no successful validations (later studies found different predictors), and the score may not apply to patients in common practice or those receiving modern targeted therapies such as sunitinib.

    There are no validated scoring systems for predicting survival in mRCC. Using a score may help suggest categories of survival time better than clinical judgment alone.

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    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    The Motzer score (which performs similarly with or without the Mekhail extension) is among the most commonly used for mRCC, and is probably best used for selecting patients to enroll in clinical trials. The score retrospectively identified variables associated with survival, which may ultimately help predict outcomes.

    Management

    We are unaware of validated management algorithms using the score.

    Critical Actions

    The Motzer score (with or without the Mekhail extension) is not known to be accurate for individual survival prediction and should be considered a general guide rather than a concrete predictor.

    About the Creator
    Dr. Tarek Mekhail
    Are you Dr. Tarek Mekhail?