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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
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    Patent Pending

    Naloxone Drip Dosing

    Doses naloxone for acute opioid overdose.


    This dosing tool is intended to assist with calculation, not to provide comprehensive or definitive drug information. Always double-check dosing of any drug and consult a pharmacist when necessary.


    Use in patients with respiratory or central nervous system depression from opioid analgesic overdose.

    When to Use
    Why Use
    • Respiratory or CNS depression from opioid analgesic overdose.
    • Respiratory depression responsive to naloxone administration.
    • Respiratory depression requiring more than one IV dose of naloxone.
    • Goal is to maintain the same level of reversal following initial naloxone bolus.
    • Bolus dose necessary to reverse the respiratory depressant effects of the opioid overdose should be determined clinically.
    • Bolus dose = total dose required in the first hour.

    The half-life of naloxone is between 30 and 100 minutes. Because the duration of action of most available opioids exceeds that of naloxone, repeated administration or a continuous IV infusion may be required to prevent recurrence of respiratory depression.



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    Next Steps
    Creator Insights


    • Consider gastric decontamination for orally ingested opioid. Look for and remove patches if applicable.
    • The drip may require frequent adjustment based on clinical status.


    Consider admission to an intensive care setting to prevent recurrent CNS and/or respiratory sequelae or withdrawal.

    Critical Actions

    • Adjust drip based on clinical status.
    • Monitor patient in a intensive care setting.
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    About the Creator
    Dr. Lewis Goldfrank
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