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    PLASMIC Score for TTP

    Predicts ADAMTS13 deficiency in suspected thrombotic thrombocytopenic purpura (TTP) with high discrimination.
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    No
    0
    Yes
    +1
    No
    0
    Yes
    +1
    No
    +1
    Yes
    0
    No
    +1
    Yes
    0
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1

    Result:

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    Evidence
    Creator Insights

    Advice

    Do you use the PLASMIC Score for TTP and want to contribute your expertise? Join our contributor team!

    Formula

    Addition of the selected points:

    Variable

    0 points

    1 point

    Platelet count <30 x 109/L

    No

    Yes

    Hemolysis*

    No

    Yes

    Active cancer**

    Yes

    No

    History of solid-organ or stem-cell transplant

    Yes

    No

    MCV <9.0 x 10-14 L (<90 fL) 

    No

    Yes

    INR <1.5

    No

    Yes

    Creatinine <2.0 mg/dL (176.8 μmol/L)

    No

    Yes

    *Reticulocyte count >2.5%, haptoglobin undetectable, or indirect bilirubin >2.0 mg/dL (34.2 µmol/L).

    **Treated for cancer within the past year.

    From Bendapudi 2017.

    Facts & Figures

    Interpretation:

    PLASMIC Score

    Risk group

    Risk of severe ADAMTS13 deficiency*

    0-4

    Low

    0%

    5

    Intermediate

    6%

    6-7

    High

    72%

    *Severe deficiency was defined as ADAMTS13 activity level <15%.

    From Li 2018.

    Dr. Pavan K. Bendapudi

    About the Creator

    Pavan K. Bendapudi, MD, is an assistant professor of medicine at Harvard Medical School in Boston, MA. He is also a co-principal investigator of the Harvard Thrombotic Microangiopathies Research Collaborative, a multi-institutional project studying TTP. Dr. Bendapudi’s primary research is focused on humoral coagulation factors and the mechanisms underlying hemostatic and thrombotic disease.

    To view Dr. Pavan K. Bendapudi's publications, visit PubMed

    About the Creator
    Dr. Pavan K. Bendapudi