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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Revised International Prognostic Scoring System (IPSS-R) for Myelodysplastic Syndrome (MDS)

    Stages patients with MDS.

    INSTRUCTIONS

    Use at the time of diagnosis, before starting treatment.

    When to Use
    Pearls/Pitfalls
    Why Use

    Patients newly-diagnosed with myelodysplastic syndrome.

    • The IPSS-R categorizes patients into 1 of 5 groups, from very low risk to very high risk, based on risk of mortality and transformation to acute myeloid leukemia (AML).
    • This score is not dynamic and is meant to be used at the time of diagnosis only. That being said, the score does get higher with disease progression.
    • The IPSS-R has better discrimination and is more widely used over the original IPSS (see Evidence).
    • Data are based on untreated patients, represent statistical probabilities, and are not absolute.

    Can help determine whether to treat or observe, and what type of treatment, based on risk score.

    Very good: del(11q) or -Y
    0
    Good: normal karyotype, del(20q), del(5q), del(12p), or double including del(5q)
    +1
    Intermediate: +8, del(7q), i(17q), +19, or any other single or double independent clone
    +2
    Poor: -7, inv(3)/t(3q)/del(3q), double including -7/del(7q), or complex (3 abnormalities)
    +3
    Very poor: complex >3 abnormalities
    +4
    ≤2
    0
    >2 to <5
    +1
    5 to 10
    +2
    >10
    +3
    ≥10 (≥100)
    0
    8 to <10 (80 to <100)
    +1
    <8 (<80)
    +1.5
    ≥100
    0
    50 to <100
    +0.5
    <50
    +1
    ≥0.8
    0
    <0.8
    +0.5

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Peter Greenberg

    About the Creator

    Peter Greenberg, MD, is professor emeritus of hematology at Stanford University. He is also director of the Stanford Myelodysplastic Syndrome (MDS) Center, coordinator of the International Working Group for Prognosis in MDS and chair of the National Comprehensive Cancer Network MDS Practice Guidelines Panel. Dr. Greenberg’s research focuses on evaluating molecular and genetic abnormalities in myelodysplastic syndromes.

    To view Dr. Peter Greenberg's publications, visit PubMed

    Are you Dr. Peter Greenberg? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    Reviewed By
    • Eytan Stein, MD
    About the Creator
    Dr. Peter Greenberg
    Are you Dr. Peter Greenberg?
    Content Contributors
    Reviewed By
    • Eytan Stein, MD