Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Revised Original Score for Autoimmune Hepatitis (AIH)

    Revised version of the original scoring system for the diagnosis of autoimmune hepatitis.
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    When to Use
    Why Use

    Patients with established hepatitis and available liver biopsy results, but unclear diagnosis.

    AIH is multifactorial, complex, and typically has many competing diagnoses. The score offers a data driven, consensus-based path to help guide treatment.

    Male
    0
    Female
    +2
    <1.5
    +2
    1.5-3.0
    0
    >3.0
    -2
    >2.0
    +3
    1.5-2.0
    +2
    1.0-1.5
    +1
    <1.0
    0
    >1:80
    +3
    1:80
    +2
    1:40
    +1
    <1:40
    0
    Seropositivity for other defined autoantibodies
    +2
    HLA-DR3 or HLA-DR4
    +1
    None of the above
    0
    Positive
    -4
    Negative
    0
    Positive
    -3
    Negative
    +3
    Yes
    -4
    No
    +1
    <25 g/day
    +2
    25-60 g/day
    0
    >60 g/day
    -2
    Yes
    +3
    No
    0
    Yes
    +1
    No
    0
    Yes
    +1
    No
    0
    Yes
    -3
    No
    0
    Yes
    -3
    No
    0
    Yes
    +2
    No
    0
    Complete
    +2
    Relapse
    +3

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    AIH is a complex diagnosis partly because there is no anatomic criterion (i.e. ’gold’) standard. The revised (1999), conventional AIH score solves this problem by defining the diagnosis, though some would say the recently developed, more specific, simplified version offers a preferred alternative.

    Management

    We are unaware of validated management algorithms using the AIH score.

    Critical Actions

    Overlap with multiple conditions is always a concern to consider, despite score findings, and ‘definite’ scores are considerably more predictive than ‘probable’ scores.

    About the Creator
    Dr. Fernando Alvarez
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