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    Serum Ascites Albumin Gradient (SAAG)

    Defines presence of portal hypertension in patients with ascites.
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    When to Use
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    Why Use

    Patients with known liver disease and ascites in whom portal hypertension status is unknown.

    • The serum ascites albumin gradient (SAAG) can determine which patients with liver disease have portal hypertension.
    • A cutoff level of 1.1 has bene validated to determine who has portal hypertension.

    Obtaining ascites fluid is relatively simple and safe in experienced operators. The constituents of ascites fluid offer a less-invasive method for gauging risk and portal hypertension status.

    g/dL
    g/dL
    About the Creator
    Dr. John Carl Hoefs
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      Result:

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      Evidence
      Creator Insights

      Advice

      The SAAG seems reliable and useful for determining portal hypertension. It is not as reliable for making pathologic diagnoses, and its value in settings outside of referral populations with liver failure is unknown. Moreover, prospective data are dominated by one SAAG validation study, suggesting future investigations have the potential to shed further light.

      Management

      We are unaware of validated management algorithms using the SAAG.

      Critical Actions

      The SAAG requires temporally similar blood and ascites fluid examinations.

      Formula

      SAAG = (albumin concentration of serum) – (albumin concentration of ascitic fluid)

      Facts & Figures

      Interpretation

      • SAAG > 1.1 g/dL indicates portal hypertension is the cause of ascites with 97% accuracy.
      • SAAG scores do not indicate the cause of the portal hypertension.
      Dr. John Carl Hoefs

      About the Creator

      John Carl Hoefs, MD, is a Professor of Medicine at University of California Irvine. He studied medicine at George Washington University in Washington DC. He currently practices and researches in the hepatology field, specifically regarding Hepatitis B, Hepatitis C, Ascites, Chronic liver disease, Liver-spleen scan and Hepatic function.

      To view Dr. John Carl Hoefs's publications, visit PubMed

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