Act on the corrected sodium level, not the measured sodium level.
Corrected Sodium (Katz, 1973) = Measured sodium + 0.016 * (Serum glucose - 100)
Corrected Sodium (Hillier, 1999) = Measured sodium + 0.024 * (Serum glucose - 100)
Facts & Figures
Hillier et. al (1999) evaluated 6 healthy subjects, induced hyperglycemia, and measured actual serum sodium levels, finding a sodium correction factor of 2.4mEq/L to be more accurate than the classically taught 1.6mEq/L correction factor from Katz, 1973.
Original/Primary ReferenceKatz MA. Hyperglycemia-induced hyponatremia--calculation of expected serum sodium depression. N Engl J Med. 1973 Oct 18;289(16):843-4. PubMed PMID: 4763428.
About the Creator
Theresa A. Hillier, MD, MS, is a practicing endocrinologist and senior investigator at the Kaiser Permanente Center for Health Research. Her research includes how modifiable risk factors earlier in life can affect future risk of endocrine diseases, including gestational diabetes, obesity, metabolic syndrome, type 2 diabetes, and osteoporosis. Dr. Hillier is currently the principal investigator of the Study of Osteoporotic Fractures (SOF),
To view Dr. Theresa A. Hillier's publications, visit PubMed