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Sodium Correction for Hyperglycemia
Calculates the actual sodium level in patients with hyperglycemia.
Hyperglycemia causes osmotic shifts of water from the intracellular to the extracellular space, causing a relative dilutional hyponatremia. The classic correction factor of 1.6 mEq/L for every 100 mg/dL increase in serum glucose was challenged by a paper by Hillier et al in 1999, and sometimes their factor of 2.4 mEq/L is used.
Hillier et. al (1999) evaluated 6 healthy subjects, induced hyperglycemia, and measured actual serum sodium levels, finding a sodium correction factor of 2.4mEq/L to be more accurate than the classically taught 1.6mEq/L correction factor from Katz, 1973.