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      Calc Function

    • Calcs that help predict probability of a diseaseDiagnosis
    • Subcategory of 'Diagnosis' designed to be very sensitiveRule Out
    • Disease is diagnosed: prognosticate to guide treatmentPrognosis
    • Numerical inputs and outputsFormula
    • Med treatment and moreTreatment
    • Suggested protocolsAlgorithm

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    Patent Pending

    Sokal Index for Chronic Myelogenous Leukemia (CML)

    Predicts survival of CML based on clinical and lab information.

    INSTRUCTIONS

    Use to predict prognosis at the time of CML diagnosis, before starting treatment.

    When to Use
    Pearls/Pitfalls
    Why Use

    In the US, the Sokal Score can be used to determine risk and decide on therapy based on the NCCN guidelines for CML. While the EUTOS score is easier to calculate and more accurately identifies high risk patients in the era of tyrosine kinase inhibitors, it has not been adopted by the NCCN guidelines.

    • The Sokal Index, also referred to as the Sokal Score, was developed using patients treated in the pre-tyrosine kinase inhibitor era and thus can not necessarily be applied today. Survival outcomes have drastically improved since then.
    • Although scores are stratified into low, intermediate, and high risk, some studies have shown that low and intermediate risk have similar outcomes.
    • Some advocate combining the Sokal and EUTOS Scores for better predictive value.
    • NCCN guidelines for CML treatment recommend use of the Sokal and Hasford Scores over EUTOS for clinical risk stratification.
    • The Sokal Score is also preferentially used in clinical trials so that comparisons can be made to prior trials.
    years
    cm
    × 10³/µL
    %

    Result:

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    Next Steps
    Evidence
    Creator Insights
    Dr. Joseph E. Sokal

    About the Creator

    Joseph E. Sokal, MD, (d. 1988) was a researcher in cancer treatment and a scholar in residence at Duke University. Previously, he was chief cancer research clinician at Roswell Park Memorial Institute in Buffalo and an assistant professor at Yale University.

    To view Dr. Joseph E. Sokal's publications, visit PubMed

    Are you Dr. Joseph E. Sokal? Send us a message to review your photo and bio, and find out how to submit Creator Insights!
    MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can be invaluable to physicians taking care of patients.
    Content Contributors
    Reviewed By
    • Michael Mauro, MD
    About the Creator
    Dr. Joseph E. Sokal
    Are you Dr. Joseph E. Sokal?
    Content Contributors
    Reviewed By
    • Michael Mauro, MD