UCLA Integrated Staging System (UISS) for Renal Cell Carcinoma (RCC)
- Localized: Any T; N0; M0
- Metastatic: T>0; N>1; M>1
- For accurate staging, see the TNM Staging for RCC calculator
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The UISS score is often used for screening and stratifying patients into modern therapy trials, including trials of VEGF therapy such as sunitinib. The consistency of results in validation studies is somewhat reassuring, and one advantage is its applicability to patients with and without metastatic disease.
We are unaware of validated management algorithms using the score.
The UISS score is complex, requiring close attention to multiple variables for correct classification.