Acute Venous Thromboembolic Disease(beta)
For patients who are at low risk for acute pulmonary embolism (PE), use the Pulmonary Embolism Rule-out Criteria (PERC) to exclude the diagnosis without further diagnostic testing.
In patients older than 50 years deemed to be low or intermediate risk for acute pulmonary embolism (PE), clinicians may use a negative age-adjusted D-dimer* result to exclude the diagnosis of pulmonary embolism. *For highly sensitive D-dimer assays using fibrin equivalent units (FEU) use a cutoff of age×10 μg/L; for highly sensitive D-dimer assays using D-dimer units (DDU), use a cutoff of age×5 μg/L.
Selected patients with acute pulmonary embolism (PE) who are at low risk for adverse outcomes as determined by Pulmonary Embolism Severity Index (PESI), simplified PESI (sPESI), or the Hestia criteria may be safely discharged from the emergency department (ED) on anticoagulation, with close outpatient follow-up.
Given the lack of evidence, anticoagulation treatment decisions for patients with subsegmental pulmonary embolism (PE) without associated deep venous thrombosis (DVT) should be guided by individual patient risk profiles and preferences. [Consensus recommendation]
In selected patients diagnosed with acute deep venous thrombosis (DVT) , a non-vitamin K antagonist oral anticoagulant (NOAC) may be used as a safe and effective treatment alternative to low-molecular-weight heparin (LMWH)/vitamin K antagonist (VKA).