Calc Function

  • Diagnosis
  • Rule Out
  • Prognosis
  • Formula
  • Treatment
  • Algorithm
  • Disease
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    Specialty
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    Chief Complaint
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    Organ System
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    Neoadjuvant Chemotherapy for Newly Diagnosed, Advanced Ovarian Cancer

    Based on guidelines from SUO and ASCO.

    Evaluation

    Stage IIIC-IV

    Strong recommendation
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    Intermediate quality evidence

    Moderate recommendation
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    Intermediate quality evidence

    Primary Cytoreductive Surgery Not Recommended

    Moderate recommendation
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    Intermediate quality evidence

    Moderate recommendation
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    Intermediate quality evidence

    Neoadjuvant Therapy vs Primary Cytoreductive Surgery

    Moderate recommendation
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    Intermediate quality evidence

    Moderate recommendation
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    Intermediate quality evidence

    Evaluation

    Moderate recommendation
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    Intermediate quality evidence

    Moderate recommendation
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    Intermediate quality evidence

    Treatment

    Neoadjuvant Chemotherapy

    Moderate recommendation
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    Intermediate quality evidence

    Interval Cytoreductive Surgery

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    Insufficient evidence

    Progressive Disease

    Strong recommendation
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    Intermediate quality evidence

    How strong is the SGO and ASCO's recommendation?

    Strong recommendation
    High confidence that recommendation reflects best practice, based on (1) strong evidence for true net effect (benefits > harms); (2) consistent results, with no or minor exceptions; (3) minor or no concerns about study quality; and/or (4) extent of panelists’ agreement.
    Moderate recommendation
    Moderate confidence that recommendation reflects best practice, based on (1) good evidence for true net effect (benefits > harms); (2) consistent results, with minor and/or few exceptions; (3) minor and/or few concerns about study quality; and/or (4) extent of panelists’ agreement.
    Some confidence that recommendation offers the best current guidance for practice, based on (1) limited evidence for true net effect (benefits > harms); (2) consistent results, but with important exceptions; (3) concerns about study quality; and/or (4) extent of panelists’ agreement.
    High quality evidence
    High confidence that available evidence reflects true magnitude and direction of net effect (i.e., balance of benefits vs harms) and that further research is very unlikely to change either magnitude or direction of this net effect.
    Intermediate quality evidence
    Moderate confidence that available evidence reflects true magnitude and direction of net effect. Further research is unlikely to alter the direction of the net effect; however, it might alter the magnitude of the net effect.
    Low quality evidence
    Low confidence that available evidence reflects true magnitude and direction of the net effect. Further research may change either the magnitude and/or direction of this net effect.
    Insufficient evidence
    Evidence is insufficient to discern true magnitude and direction of net effect. Further research may better inform the topic. The use of the consensus opinion of experts is reasonable to inform outcomes related to the topic.