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    Patent Pending

    Ankylosing Spondylitis Disease Activity Score with CRP (ASDAS-CRP)

    Stratifies severity of ankylosing spondylitis (AS) using clinical and laboratory data, specifically CRP.
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    Pearls/Pitfalls
    Why Use

    Other than CRP, all values are self-reported by the patient and therefore subjective.

    • The ASDAS-CRP is the preferred disease activity index according to the Assessment of SpondyloArthritis international Society (ASAS).

    • May be useful for trending disease activity over time.

    0: least severe
    0
    1
    +1
    2
    +2
    3
    +3
    4
    +4
    5
    +5
    6
    +6
    7
    +7
    8
    +8
    9
    +9
    10: most severe
    +10
    0: least severe
    0
    1
    +1
    2
    +2
    3
    +3
    4
    +4
    5
    +5
    6
    +6
    7
    +7
    8
    +8
    9
    +9
    10: most severe
    +10
    0: least severe
    0
    1
    +1
    2
    +2
    3
    +3
    4
    +4
    5
    +5
    6
    +6
    7
    +7
    8
    +8
    9
    +9
    10: most severe
    +10
    0: least severe
    0
    1
    +1
    2
    +2
    3
    +3
    4
    +4
    5
    +5
    6
    +6
    7
    +7
    8
    +8
    9
    +9
    10: most severe
    +10
    mg/L

    Result:

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    Next Steps
    Evidence
    Creator Insights

    Advice

    May be useful in helping to guide treatment decisions; e.g. detecting improvement with TNF inhibitors.

    Formula

    ASDAS-CRP = (0.12 x back pain) + (0.06 x morning stiffness) + (0.11 x patient global assessment of disease activity) + (0.07 x peripheral pain/swelling) + (0.58 x ln(CRP + 1))

    Where variables are:

    Back pain

    Ask the patient: "How would you describe the overall level of AS neck, back, or hip pain you have had?"

    Morning stiffness

    Ask the patient: "How would you describe the overall level of morning stiffness you have had from the time you wake up?"

    Patient global assessment of disease activity

    Ask the patient: "How active was your spondylitis, on average, during the last week?"

    Peripheral pain/swelling

    Ask the patient: "How would you describe the overall level of pain/swelling in joints other than neck, back, or hips you have had?"

    CRP

    C-reactive protein, mg/L

    All variables, except CRP, should be graded on a scale of 0 (least severe) to 10 (most severe).

    Facts & Figures

    Interpretation:

    ASDAS-CRP

    Disease activity

    <1.3

    Inactive

    1.3-2.0

    Low

    2.1-3.5

    High

    >3.5

    Very high

    Dr. Cédric Lukas

    About the Creator

    Cédric Lukas, MD, PhD, is an associate professor of rheumatology at University Hospital Lapeyronie in Montpellier, France. He is a member of the EULAR Research Center in Montpellier. Dr. Lukas’ primary research is focused on autoimmune disease, inflammatory disease, and clinical rheumatology.

    To view Dr. Cédric Lukas's publications, visit PubMed